Dyspnea in Stable Patients With Coronary Artery Disease.

  • STATUS
    Recruiting
  • days left to enroll
    25
  • participants needed
    200
  • sponsor
    National Research Center for Preventive Medicine
Updated on 4 September 2021
angiography
stenosis
myocardial infarction
angina pectoris
infarct
ischemia
coronary artery stenosis
exercise stress test
arterial disease

Summary

Single-centre prospective study to characterize causes of dyspnea in stable patients with coronary artery disease and evaluate the possibility to determine the cause of dyspnea before in-depth examination.

Description

Stable patients with dyspnea and coronary artery disease will be included in this single-centre prospective study. In addition to routine clinical examination patients will be interviewed to determine the nature of shortness of breath, angina, presence of chronic heart failure or anxiety using the Medical Research Council Dyspnea scale, the visual analog scale of dyspnea, Borg scale, modified "dictionary" of dyspnea, G. Rose questionnaire, Seattle Angina Questionnaire, Framingham criteria for chronic heart failure and the SHOCK scale. During the subsequent in-depth examination including thyroid hormones, NT-proBNP, hsTroponin, ECG monitoring, six-minute walk test, stress-echo with a diastolic stress test, spirometry and coronary angiography (if necessary) main reason for dyspnea will be established. Possibilities of early (before in-depth examination) determination the reason for dyspnea in stable patients with coronary artery disease will be evaluated.

Details
Condition difficulty breathing, Dyspnea, breathlessness, Coronary heart disease, respiratory difficulties, Coronary Artery Disease, Myocardial Ischemia, breathing difficulty, breathless, Cardiac Ischemia, breathing difficulties, shortness of breath, trouble breathing
Treatment Scales for assessment of symptoms
Clinical Study IdentifierNCT04408612
SponsorNational Research Center for Preventive Medicine
Last Modified on4 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Stable patients with shortness of breath and established diagnosis of coronary artery disease (at least 1 of the following signs)
history of myocardial infarction
typical angina without suspected other cause of pain
myocardial ischemia documented by ECG changes during symptoms and/or by results of the stress test
coronary artery stenosis >50% according to coronary angiography
Signed informed consent

Exclusion Criteria

Acute coronary syndrome (myocardial infarction, unstable angina) in the previous month
Hospitalization with decompensation of CHF in the previous 6 months (including CHF decompensation as the main reason for current hospitalization)
Diseases with an unfavourable prognosis (terminal CKD, CHF NYHA IV, a lung disease with severe respiratory failure)
Contraindications to bicycle stress echocardiography
Atrial Fibrillation at the time of hospitalization, when the decision not to restore the sinus rhythm
Mental illnesses and disorders, dementia, drug or alcohol dependence
Known oncological diseases
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note