TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children

  • STATUS
    Recruiting
  • End date
    Jun 24, 2024
  • participants needed
    17
  • sponsor
    Johns Hopkins All Children's Hospital
Updated on 24 January 2021
stroke
immunosuppressant
stem cell transplantation
anemia
hla-a
hydroxyurea
pulmonary function test
blood disorder
hemoglobin s
gilbert's syndrome
oximetry
progressive disease
blood transfusion
immunosuppression
fibrosis
aplastic anemia
pancytopenia
diamond-blackfan anemia
neutropenia
immune thrombocytopenia
chelation therapy
acute chest syndrome
chest syndrome
sickle cell anemia
hematologic disorders
thalassemia
bone marrow failure syndromes
thrombasthenia
haploidentical hematopoietic cell transplantation

Summary

This research is being done to learn if a new type of haploidentical transplantation using TCR alpha beta and CD19 depleted stem cell graft from the donor is safe and effective to treat the patient's underlying condition. This study will use stem cells obtained via peripheral blood or bone marrow from parent or other half-matched family member donor. These will be processed through a special device called CliniMACS, which is considered investigational.

Details
Condition Hemoglobinopathy, Severe Aplastic Anemia, Bone Marrow Failure Syndrome, Bone Marrow Failure Syndromes, Bone Marrow Failure Disorders, hemoglobinopathies
Treatment Haploidentical Hematopoietic Cell Transplantation
Clinical Study IdentifierNCT04356469
SponsorJohns Hopkins All Children's Hospital
Last Modified on24 January 2021

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