Association Between Anesthetic Drugs for General Anesthesia and Postoperative Intelligence/Behavioral Assessment Results in Children

  • End date
    Dec 30, 2028
  • participants needed
  • sponsor
    Seoul National University Hospital
Updated on 29 September 2021


In this study, we compared the results of the intelligence and behavioral test performed after surgery between the group using sevoflurane and the group receiving dexmedetomidine and remifentanil, in Korean children under 2 years of age who underwent surgery under general anesthesia.

Condition Anesthesia and Neurotoxicity
Treatment Dexmedetomidine, Sevoflurane, Remifentanil
Clinical Study IdentifierNCT04364945
SponsorSeoul National University Hospital
Last Modified on29 September 2021


Yes No Not Sure

Inclusion Criteria

Children under 2 years of age who underwent general anesthesia for elective surgeries of urology, surgery, plastic surgery, orthopedics, and otolaryngology
American Society of Anesthesiology Physical Status I, II

Exclusion Criteria

Allergies to narcotic analgesics
With massive bleeding or shock
Heart, lung, kidney or liver disease
Central / peripheral nervous system disease and disorder
Any physical deformity and disorder, genetic disease, chromosomal disease
Previous history of general anesthesia or sedation
Additional exposure to general anesthetics or sedative drugs during follow-up
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