The Effectiveness of Lactoferrin in the Management of Treatment-induced Anemia

  • End date
    Jun 20, 2023
  • participants needed
  • sponsor
    Cyprus University of Technology
Updated on 7 October 2022
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This will be a randomised control trial designed to test the effectiveness of lactoferrin in the management of treatment-induced anemia in patients with hematological malignancies.


Chemotherapy induced anemia (CIA) is a common adverse event in cancer patients reported to occur in 20-60% whilst the resulting low hemoglobin level is associated with impaired quality of life. Lactoferrin (LF) is a non-haem iron-binding protein that is part of the transferrin protein family, along with serum transferrin, ovotransferrin, melanotransferrin and the inhibitor of carbonic anhydrase, whose function is to transport iron in blood serum.

The aim of the study is to test the effectiveness of LF along with standard care in the management of treatment-induced anemia.

Condition Anemia
Treatment Recombinant human Erythropoietin, Lactoferrin
Clinical Study IdentifierNCT03683810
SponsorCyprus University of Technology
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Patients on active treatment (chemotherapy i.e. cyclophosphamide, doxorubicin, rituximab, cisplatin carboplatin, etoposide)
Ability to independently complete the questionnaires

Exclusion Criteria

Allergy to Milk
Lactose intolerance
Celiac disease
Patient of whom chemotherapy has been interrupted for more than 2 weeks (due to adverse effects)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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