Deep Transcranial Magnetic Stimulation for the Treatment of Treatment Resistance Schizophrenia
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- STATUS
- Recruiting
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- End date
- Dec 30, 2022
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- participants needed
- 40
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- sponsor
- Shanghai Mental Health Center
Summary
Based on the hypothesis that low-frequency deep transcranial magnetic stimulation(dTMS) on anterior cingulate cortex ACC could down-regulate the glutamate level of ACC and regulate the acc-related functional network in patients with treatment resistance schizophrenia,this research plan to utilise multimodal functional magnetic imaging method(including structural MRI,resting-state functional magnetic resonance imaging and 1H-MRS) to investigate therapeutic efficacy of low-frequency deep transcranial magnetic stimulation on SZ patients symptoms,as well as to elucidate the correlation between treatment effects and glutamate level of ACC
Description
This study includes 20 treatment resistance schizophrenia patients and 20 healthy controls.This study will investigate 1)abnormalities of the glutamate level of ACC in patients with schizophrenia compared to healthy controls by using 1H-MRS technique. 2)potential modulation effects of deep transcranial magnetic stimulation(dTMS) on anterior cingulate cortex function of patients with schizophrenia. 3)the therapeutic efficacy of dTMS on cognitive impairments and other psychotic symptoms of patients with schizophrenia by adopting cognitive function and psychotic symptoms evaluation,as well as to explore the optimal dTMS treatment pattern on cognitive function.
Details
| Condition | Deep Transcranial Magnetic Stimulation for the Treatment of Treatment Resistance Schizophrenia |
|---|---|
| Treatment | deep transcranial magnetic stimulation with H7 coil |
| Clinical Study Identifier | NCT04478032 |
| Sponsor | Shanghai Mental Health Center |
| Last Modified on | 23 September 2021 |
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