Parallel Mapping for Ventricular Tachycardia

  • days left to enroll
  • participants needed
  • sponsor
    The Cleveland Clinic
Updated on 23 March 2022
ventricular tachycardia
catheter ablation
antiarrhythmic drug
sustained ventricular tachycardia


Catheter ablation in patients with ventricular tachycardia using a new mapping algorithm called, parallel mapping, that is aimed to increase the specificity of mapping and the outcome of ablation.


In patients with scar in the hearts after heart attacks, the risk for dangerous abnormal heart rhythms, including sudden death is high. This is because dead muscle fibers are replaced by scar tissue, creating a physiological condition promoting abnormal heart rhythms.These abnormal heart rhythms are called ventricular arrhythmias or ventricular tachycardias. In these patients, ablation procedures can be helpful, however the recurrence rate of arrhythmias after ablation remains unacceptably high. The primary reason for this high recurrence rate is nonspecific mapping methodologies for identifying the heart area responsible for these arrhythmias. Therefore, new methods for increasing the specificity of mapping have been the subject of significant research for many years, however implementation of these methods in clinical practice has been challenged by limited technologies. Recently, a new mapping technology named "parallel mapping" has been developed, received FDA approval and is routinely utilized at the Cleveland Clinic. However, the workflow of using parallel mapping, and the efficacy of ablation using this technology have not been evaluated.

Condition Ventricular Tachycardia (V-Tach), Implantable Cardioverter Defibrillator (ICD), Arrythmia
Clinical Study IdentifierNCT04477499
SponsorThe Cleveland Clinic
Last Modified on23 March 2022


Yes No Not Sure

Inclusion Criteria

Age ≥18 years
History of scar-mediated sustained ventricular tachycardia
Failure of therapy with Anti arrhythmic drugs
Implanted ICD or a plan for ICD implantation after the ablation
Willingness to adhere to the study restrictions and comply with all post procedural follow-up requirements
Ability to understand the requirements of the study and sign an informed consent

Exclusion Criteria

Patients with reversible causes of ventricular tachycardia including ongoing ischemia or electrolyte abnormalities
Contraindication to anticoagulation therapy
Stroke within 30 days before enrollment
Life expectancy <1 year
Individual has a known, unresolved history of drug use or alcohol dependency lacks the ability to comprehend or follow instructions or would be unlikely or unable to comply with study follow-up requirements
Pregnant or breast feeding at time of signing consent
Patient undergoing cardiac transplantation
Enrolled or participates in other drug or device studies
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