A Study of DNL310 in Pediatric Participants With Hunter Syndrome

  • STATUS
    Recruiting
  • End date
    Mar 12, 2024
  • participants needed
    30
  • sponsor
    Denali Therapeutics Inc.
Updated on 12 November 2021
enzyme replacement therapy
mucopolysaccharidosis
iduronate 2-sulfatase

Summary

This is a multicenter, multiregional, open-label study to assess the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of DNL310, an investigational central nervous system (CNS)-penetrant enzyme replacement therapy (ERT), designed to treat both the peripheral and CNS manifestations of Mucopolysaccharidosis type II (MPS II; Hunter syndrome).

The study has three cohorts:Cohort A will enroll participants with neuronopathic MPS II aged 5 to 10 years; Cohort B will enroll participants with MPS II, either neuronopathic or non-neuronopathic, aged 2 to 18 years; and Cohort C will enroll participants with neuronopathic MPS II aged 2 and <4 (Cohort C can include nMPS II participants 4 if the participant is a sibling of a participant aged 2 and <4).

Participants, whose physicians feel they are deriving benefit, will have the opportunity to be reconsented into a safety extension for continued evaluation.

Details
Condition Hunter's Syndrome, Hunter Syndrome (MPS II)
Treatment DNL310
Clinical Study IdentifierNCT04251026
SponsorDenali Therapeutics Inc.
Last Modified on12 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Confirmed diagnosis of MPS II
Cohort A: Participants aged 5 to 10 years with neuronopathic MPS II
Cohort B: Participants aged 2 to 18 years with non-neuronopathic MPS II, neuronopathic MPS II, or unknown phenotype
Cohort C: Participants aged 2 to <4 years with neuronopathic MPS II (this cohort can include participants 4 years of age if participant is a sibling of a participant 2 to <4 years of age)
For participants receiving intravenous iduronate 2-sulfatase (IDS) ERT, tolerated a minimum of 4 months of therapy during the period immediately prior to screening

Exclusion Criteria

Unstable or poorly controlled medical condition(s) or significant medical or psychological comorbidity or comorbidities that, in the opinion of the investigator, would interfere with safe participation in the trial or interpretation of study assessments
Use of any CNS-targeted MPS II ERT within 3 months before study start for participants aged 5 years, and within 6 months before study start for participants aged <5 years
Use of IDS gene therapy or stem cell therapy at any time
Clinically significant thrombocytopenia, other clinically significant coagulation abnormality, or significant active bleeding, or required treatment with an anticoagulant or more than two antiplatelet agents
Contraindication for lumbar punctures
Have a clinically significant history of stroke, status epilepticus, head trauma with loss of consciousness, or any CNS disease that is not MPS II-related within 1 year of screening
Have had a ventriculoperitoneal (VP) shunt placed, or any other brain surgery, or have a clinically significant VP shunt malfunction within 30 days of screening
Have any clinically significant CNS trauma or disorder that, in the opinion of the investigator, may interfere with assessment of study endpoints or make participation in the study unsafe
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