Impact of the Comprehensive Geriatric Assessment on the Quality of Life OF Elderly Patients

  • STATUS
    Recruiting
  • End date
    May 25, 2022
  • participants needed
    144
  • sponsor
    Lorenza Scotti
Updated on 25 January 2021
cancer
hematologic malignancy

Summary

Impact of the Comprehensive Geriatric Assessment on the Quality of Life of elderly onco-hematologic patients' candidates for complex antitumoral therapies: clinical and biological correlatives

Description

The screenings for the next 2 decades indicate an exponential increase in the incidence of neoplastic diseases in the elderly population. In order to successfully balance effectiveness and low toxicity of immunochemotherapy, a treatment personalisation based on an objective evaluation of fitness is therefore needed. The use of geriatric screening is a first step to rationalize decisions in this regard, the G8 tool has demonstrated the ability to identify patients and mostly to objectively separate elderly fragile patients from those who are fit. In that consideration, the individualization of the anticancer treatment based on a Comprehensive Geriatric Assessment (CGA) is desirable in elderly fragile patients with solid or haematological malignancy. Cancer mortality is constantly increasing after 65 years and the consequent increase in life expectancy favour the processes of cellular senescence. In this context G8 fragility assessment will take place in the screening test and by using the EORTC QLQ-C30C questionnaire to assess quality of life (QoL). The evaluation of senescent cells will be done by real-time PCR. Our aims are i) to evaluate the impact of the CGA on the QoL of elderly onco-haematological patients, candidates for complex therapies, that resulted as fragile at the G8 geriatric screening and ii) to evaluate the senescent cells in the peripheral blood of the patients enrolled in the study. The study is expected to contribute to precision medicine management of elderly patients and refine the therapeutic stratifications.

Details
Condition Hematologic Malignancy, Blood disorder, Solid Tumors, Solid Tumor, Solid Neoplasm, Elderly Patients, Solid Tumour, Blood Cancer, Hematologic Cancer, Hematological Disorders, Hematologic Neoplasms, Hematologic Malignancies, Elderly, Solid Tumor, Elderly, Hematologic Malignancies, Elderly, Solid Tumor, Elderly, hematological malignancy, hematologic malignancies, hematological tumor, haematological malignancy, hematological malignancies
Clinical Study IdentifierNCT04478916
SponsorLorenza Scotti
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients aged 65 years
Diagnosis of solid or hematologic cancer
Patients who are candidates for a first line therapy for advanced disease to be treated with biological target drugs, or candidates for integrated radiotherapy
Patient with G8 scores 14/17

Exclusion Criteria

Patients aged less than 65 years
Patients who have received or currently in treatment for solid or hematologic cancer
Patient with G8 scores more than 14/17
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