Extracorporeal Blood Purification as a Treatment Modality for COVID-19

  • STATUS
    Recruiting
  • days left to enroll
    81
  • participants needed
    35
  • sponsor
    Zan Mitrev Clinic
Updated on 24 January 2021
pneumonia
SARS

Summary

Several studies have suggested a potential clinical benefit of controlling hyper inflammation triggered by SARS-CoV-2/COVID-19. Blood purification, the removal of excessive proinflammatory mediators may control disease progression and support clinical recovery.

For this purpose, COVID-19 patients might benefit from treatment with AN69ST hemofilter based extracorporeal blood purification.

Description

COVID-19 disease progression is associated with dysregulated immunity, commonly referred to as cytokine storm, in particular, aberrant Interleukin (IL) 6 levels that promote numerous pathological downstream effects. Hyperinflammation is a well-established trigger of multiorgan failure, for example, acute kidney injury. Moreover, recent reports point to a link between hyper inflammation and COVID-19 induced coagulopathy as a result of increased production of clotting factors by the liver.

Despite several lines of evidence pointing to a potential clinical benefit of controlling hyperinflammation triggered by COVID-19, management of COVID-19 remains mostly supportive built around continuous respiratory support.

To this end, considering the underlying immunological character of COVID-19 disease and the high risk of SARS-CoV-2 hyperinflammation to trigger ARDS, hypercoagulability and Acute Kidney Injury (AKI) this study aims to monitor selected biochemical, immunological and coagulation parameters in combination with radiological imaging to guide clinical practice and to tailor therapy consisting of 1) early initiation of blood purification using the oXiris (AN69ST) filter, 2) systemic heparinisation and 3) respiratory support

Details
Condition COVID19
Treatment Extracorporeal blood purification using the oXiris® (AN69ST) hemofilter
Clinical Study IdentifierNCT04478539
SponsorZan Mitrev Clinic
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have COVID19?
Do you have any of these conditions: Do you have COVID19??
Confirmed COVID-19 disease
RT-PCR
Atypical Pneumonia; X-Ray and/or Computed Tomography
oXiris blood purification cycle

Exclusion Criteria

Pregnancy
Heart failure; severe systolic dysfunction, left ventricular ejection fraction < 25% requiring urgent surgery
Aortic Aneurysms, dissection or rupture requiring urgent surgery
Recent Myocardial Infarction; cardiovascular disease patients requiring urgent surgery
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