Use of the SpiderMass for in Vivo Analysis of the Skin in Five Chronic Inflammatory Dermatosis

  • STATUS
    Recruiting
  • participants needed
    220
  • sponsor
    Pierre Fabre Dermo Cosmetique
Updated on 25 September 2021
antibiotic therapy
antibiotics
edema
bacterial infection
erythema
tacrolimus
skin disorder
retinoids
isotretinoin
rosacea
topical product
seborrheic dermatitis
sunburn
atopic dermatitis
psoriasis
desquamation
acne
vitamin d
autoimmune disease
fatty acid
atopy
eczema
vitamin
dandruff
phototherapy
scar
gout
antifungal agents
anti-fungal
inflammatory dermatosis
lichenification
vinegar
retinoid
excoriation
crust
oedema
contact dermatitis
ftir spectroscopy
essential oils
dermatosis
contact eczema
anti-dandruff

Summary

The physiological states of the skin are characterized by a certain homeostasis linked to the balance of the metabolic pathways. When these pathways are deregulated, the proteic, lipidic and metabolic is affected. It is thus possible to follow a change in the state of the skin by looking at change in the associated molecular profile.

The PRISM laboratory (INSERM U1192) in Lille has developed an innovative system laser called SpiderMass composed of 4 parts:

  1. A laser used for the micro-sampling of material in vivo,
  2. A transport transfer line of the ablated particles,
  3. A mass spectrometer that analyzes them in real time and generates the molecular profiles of the epidermis,
  4. A data analysis procedure.

The SpiderMass(TM) is of great interest for the study of the skin because it allows non-invasive vivo characterization, and therefore without biopsy or sample preparation. In addition, it will complement techniques already used in the research center such as FTIR spectroscopy. Indeed, in acne studies the FTIR allows to obtain only the Fatty Acid Triglycerid ratio while the SpiderMass permits to detail these lipid classes by each observed molecule on the surface of the skin and follow their evolution.

Details
Condition Rosacea, Eczema, Seborrheic dermatitis, Acne Vulgaris, Dermatosis, ATOPIC DERMATITIS, Dermatitis, healthy, Eczema (Atopic Dermatitis), Dermatitis, Atopic, Hand Dermatitis, Eczema (Atopic Dermatitis - Pediatric), Psoriasis Vulgaris, Congenital Skin Diseases, Eczéma (Dermatite Atopique), Dermatite Atopique, Acne, Skin Conditions, Seborrhea, acnes
Treatment in-vivo mesure, Scotch, Lipid index, Absorbant paper, Hydratation Index, TransEpidermal Water Loss, TransEpidermal Water Loss
Clinical Study IdentifierNCT04472546
SponsorPierre Fabre Dermo Cosmetique
Last Modified on25 September 2021

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