Lifestyle Intervention for Patients With Impaired Glucose Regulation

STATUS

Recruiting
End date

Dec 31, 2022
participants needed

150
sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

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Updated on 24 July 2021

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fasting

glucose tolerance test

low fat diet

low carbohydrate diet

Summary

Impaired glucose regulation (IGR) is closely related to overweight/obesity. By studying different dietary patterns (energy-limited diet vs. low-carbohydrate diet) and intensive lifestyle interventions combined with blood glucose monitoring, glucose regulation of overweight/obesity is affected. To improve the blood glucose and related metabolic indexes of patients with impaired (IGR), establish 1-2 clinical intervention programs for impaired glucose regulation.

Details

Condition	Overweight and Obesity
Treatment	Low fat diet intensive intervention, Low-Carbon Water Diet Intensive Intervention
Clinical Study Identifier	NCT04469400
Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University
Last Modified on	24 July 2021

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Age 18-65 years old Fasting blood glucose is between 5.6-6.9 mmol/L (100-125mg/dL) or oral glucose tolerance test (OGTT) 2h plasma glucose (2h-PG) is 7.8-11.1 mmol/L (140-200 mg/dL)
	kg/m2 BMI 35 kg/m2
	Those who are willing to accept assessment and sign informed consent
Exclusion Criteria
	Patients diagnosed with diabetes or undergoing diabetes treatment
	Receiving drugs or surgery for weight loss at present or in the past 3 months
	Receiving corticosteroid or thyroid hormone treatment
	Secondary obesity caused by endocrine, genetic, metabolic and central nervous system diseases
	Patients with abnormal liver function (alanine aminotransferase or/and aspartate aminotransferase exceeding the upper limit of normal value 3 times); patients with abnormal renal function (serum creatinine exceeding the upper limit of normal value); suffering from kidney disease and other diseases that need to control protein intake
	Diseases affecting the digestion and absorption of food (such as chronic diarrhea, constipation, severe gastrointestinal inflammation, active gastrointestinal ulcer, gastrointestinal resection, cholecystitis/cholecystectomy, etc.); Suffering from cardiovascular and cerebrovascular diseases, grade 3 hypertension, chronic hepatitis, malignant tumors, anemia, mental illness and memory disorders, epilepsy and other diseases; Suffering from infectious diseases such as active tuberculosis and AIDS; During pregnancy or lactation; Patients with physical disabilities and clinicians think it is not suitable to participate in the study (for example, have a serious disease not included in the discharge criteria) or are unwilling to participate in this study

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Lifestyle Intervention for Patients With Impaired Glucose Regulation