Lifestyle Intervention for Patients With Impaired Glucose Regulation

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    150
  • sponsor
    Second Affiliated Hospital, School of Medicine, Zhejiang University
Updated on 24 July 2021
fasting
glucose tolerance test
low fat diet
low carbohydrate diet

Summary

Impaired glucose regulation (IGR) is closely related to overweight/obesity. By studying different dietary patterns (energy-limited diet vs. low-carbohydrate diet) and intensive lifestyle interventions combined with blood glucose monitoring, glucose regulation of overweight/obesity is affected. To improve the blood glucose and related metabolic indexes of patients with impaired (IGR), establish 1-2 clinical intervention programs for impaired glucose regulation.

Details
Condition Overweight and Obesity
Treatment Low fat diet intensive intervention, Low-Carbon Water Diet Intensive Intervention
Clinical Study IdentifierNCT04469400
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University
Last Modified on24 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18-65 years old Fasting blood glucose is between 5.6-6.9 mmol/L (100-125mg/dL) or oral glucose tolerance test (OGTT) 2h plasma glucose (2h-PG) is 7.8-11.1 mmol/L (140-200 mg/dL)
kg/m2 BMI 35 kg/m2
Those who are willing to accept assessment and sign informed consent

Exclusion Criteria

Patients diagnosed with diabetes or undergoing diabetes treatment
Receiving drugs or surgery for weight loss at present or in the past 3 months
Receiving corticosteroid or thyroid hormone treatment
Secondary obesity caused by endocrine, genetic, metabolic and central nervous system diseases
Patients with abnormal liver function (alanine aminotransferase or/and aspartate aminotransferase exceeding the upper limit of normal value 3 times); patients with abnormal renal function (serum creatinine exceeding the upper limit of normal value); suffering from kidney disease and other diseases that need to control protein intake
Diseases affecting the digestion and absorption of food (such as chronic diarrhea, constipation, severe gastrointestinal inflammation, active gastrointestinal ulcer, gastrointestinal resection, cholecystitis/cholecystectomy, etc.); Suffering from cardiovascular and cerebrovascular diseases, grade 3 hypertension, chronic hepatitis, malignant tumors, anemia, mental illness and memory disorders, epilepsy and other diseases; Suffering from infectious diseases such as active tuberculosis and AIDS; During pregnancy or lactation; Patients with physical disabilities and clinicians think it is not suitable to participate in the study (for example, have a serious disease not included in the discharge criteria) or are unwilling to participate in this study
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