Treatment of Exercise-Induced Pulmonary Vascular Dysfunction in Symptomatic Patients After Pulmonary Thromboendarterectomy

  • STATUS
    Recruiting
  • End date
    Jun 30, 2023
  • participants needed
    20
  • sponsor
    University of Colorado, Denver
Updated on 4 October 2022

Summary

This is an open label study of Riociguat in patients with continued exercise intolerance at least 6 months following pulmonary endarterectomy (PEA).

Details
Condition Chronic Thromboembolic Disease (CTED), Exercise Intolerance Post PEA Surgery
Treatment Adempas
Clinical Study IdentifierNCT03409588
SponsorUniversity of Colorado, Denver
Last Modified on4 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult patients who underwent PTE for Chronic thromboembolic pulmonary hypertension (CTEPH) at least six months prior to screening and report ongoing subjective exercise limitation
able to give consent
able to perform a exercise protocol

Exclusion Criteria

Patients with known Residual Pulmonary Hypertension (RPH) by RHC following PTE for CTEPH
ongoing PAH-specific vasodilator therapy
known contraindication to riociguat
a physical limitation to completing an exercise protocol
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