OCT-Angiography and Adaptive Optics in Patients With Memory Impairment

  • STATUS
    Recruiting
  • End date
    Jun 25, 2023
  • participants needed
    450
  • sponsor
    Fondation Ophtalmologique Adolphe de Rothschild
Updated on 25 January 2021
angiography
cognitive impairment
dementia
optical coherence tomography
alzheimer's disease
mild cognitive impairment
memory impairment
neurodegenerative disorders
pick's disease
cognitive disorder
neurodegenerative diseases
dementia, frontotemporal
neurodegenerative disorder
cognitive disorders

Summary

Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases.

These retinal anomalies objectified by OCT-A (Optical coherence tomography angiography) and adaptive optics (AO) appear different depending on the pathologies and could therefore serve as markers in vivo of the pathophysiological processes underlying NCD.

No study to date has studied the retina and its vessels in NCD using adaptive optics. In this pilot study, we are proposing a combination of two new ophthalmological imaging techniques (OCT-A and AO), which allow rapid in vivo analysis in a completely non-invasive way of the morphology of small vessels as well as architecture of the retina to better specify the retinal anomalies associated with NCD. We will compare the parameters in OCT-A and AO between patients with NCD and controls without NCD (with memory complaint or without) and will seek to determine if there are different profiles according to the causes of NCD.

Details
Condition Lewy Body Disease, Amnesia, Dementia, Alzheimer's Disease, Parkinsons Disease With Dementia, Memory Loss, Lewy Body Dementia, diffuse lewy body disease, alzheimer, dementia alzheimer's type, loss of memory
Treatment Ophthalmological exam
Clinical Study IdentifierNCT04389437
SponsorFondation Ophtalmologique Adolphe de Rothschild
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient presenting in memory consultation for memory complaint or person accompanying a patient in memory consultation for memory complaint

Exclusion Criteria

pregnant or lactating women
history of known non-degenerative neurological pathology (tumor, stroke territorial, in particular multiple sclerosis)
history of retinal pathology
ametropia greater in absolute value than 3 diopters on the sphere, and 1.5 diopters on the cylinder
history of taking ethambutol or synthetic antimalarial
Mini Mental State Score (MMS) and / or Montreal Cognitive Assessment (MoCA) <10 for patients and 26 for accompanying persons
MRI contraindication (for patients only)
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar
Name

Primary Contact

site
Name

Phone Email

0/250
Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note