Research of the Consequences on the Digestive Tract Following the Proposed Treatments for a Urinary Infection in Children

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    Centre Hospitalier Intercommunal Creteil
Updated on 26 November 2021
antibiotic therapy
infection in children
beta lactamase


The emergence of extended-spectrum beta-lactamase-producing Enterobacteriaceae (E-ESBL) is a major public health problem. It leads more frequent prescription of penems with the risk of emergence and spread of strains producing carbapenemases, which may be resistant to all known antibiotics. A policy of savings of penems is desirable. Among the alternatives to penems, amikacin is in the foreground. It remains active on the majority of E-ESBL strains. Some risk factors for E-ESBL emergence are known: recent antibiotic therapy (particularly quinolones and cephalosporins third generation), previous hospitalization or residence in a high endemic country.

In pediatrics, E-ESBLs are primarily responsible for urinary tract infection. In France, E-ESBLs represent about 10% of the strains responsible for urinary tract infections. The Pathology Group Pediatric Infectious (GPIP) of the French Society of Pediatrics (SFP) and the Society of Infectious Pathology French Language (SPILF) have proposed different therapeutic options to treat febrile UTIs in children: amikacin intravenous; intravenous (IV) ceftriaxone or intramuscular (IM); or cefixime per-os (PO).

The objective of this study is to compare the emergence of E-ESBLs in stools of children after febrile UTIs treatment with amikacin IV versus ceftriaxone or cefixime.

Condition recurrent utis, urinary tract infection (uti), Recurrent Urinary Tract Infections, Urinary Tract Infections in Children, urinary infection, Urinary Tract Infections, Recurrent Urinary Tract Infection, Urinary tract infection
Treatment amikacin, usual antibiotic treatment
Clinical Study IdentifierNCT03825874
SponsorCentre Hospitalier Intercommunal Creteil
Last Modified on26 November 2021


Yes No Not Sure

Inclusion Criteria

Infant and child (age 3 months and <3 years)
Patient treated for febrile urinary tract infection as monotherapy with amikacin IV, ceftriaxone (IV or IM) or cefixime PO
Whose parents read and understood the newsletter and whose express consent was collected
Patient affiliated to a social security scheme (Social Security or Universal Medical Coverage)

Exclusion Criteria

Child treated with more than one antibiotic (eg treatment with dual therapy ceftriaxone / cefotaxime and aminoglycoside)
Antibiotherapy in progress or discontinued in the previous 7 days
Hospitalized child
Refusal of one of the parents
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