A Study of ZW25 (Zanidatamab) in Subjects With Advanced or Metastatic HER2-Amplified Biliary Tract Cancers

  • End date
    Jan 13, 2023
  • participants needed
  • sponsor
    Zymeworks Inc.
Updated on 13 December 2021


This multicenter, open-label, single-arm trial will evaluate the anti-tumor activity of ZW25 (zanidatamab) monotherapy in subjects with human epidermal growth factor receptor 2 (HER2)-amplified, inoperable and advanced or metastatic biliary tract cancer (BTC), including intra-hepatic cholangiocarcinoma (ICC), extra-hepatic cholangiocarcinoma (ECC), and gallbladder cancer (GBC).

Condition HER2-amplified Biliary Tract Cancers
Treatment ZW25 (Zanidatamab), In situ hybridization (ISH)-based companion diagnostic assay, Immunohistochemistry (IHC)-based companion diagnostic assay
Clinical Study IdentifierNCT04466891
SponsorZymeworks Inc.
Last Modified on13 December 2021


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Inclusion Criteria

Histologically- or cytologically-confirmed BTC, including ICC, ECC or GBC
Locally advanced or metastatic BTC and not eligible for curative resection, transplantation, or ablative therapies
Received at least 1 prior gemcitabine-containing systemic chemotherapy regimen for advanced disease, and experienced disease progression after or developed intolerance to the most recent prior therapy. For subjects who received gemcitabine in prior adjuvant or neoadjuvant treatment, if progression occurred < 6 months from the latter of primary surgical resection or completion of gemcitabine-containing adjuvant therapy, they will be considered as having received 1 prior line of therapy for advanced disease
Subjects must test positive for HER2 amplification by ISH-assay at a central laboratory on a new biopsy or archival tissue. Note that fine needle aspirates (FNAs; cytology samples) and biopsies from sites of bone metastases are not acceptable. Testing may occur at any time after diagnosis of advanced or metastatic disease and before study enrollment
Male or female, ≥18 years of age (or the legal age of adulthood per country-specific regulations)
Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1
Adequate organ function
Adequate cardiac function, as defined by left ventricular ejection fraction ≥ 50%

Exclusion Criteria

Received systemic anti-cancer therapy within 3 weeks of the first dose of ZW25. Received radiotherapy within 2 weeks of the first dose of ZW25
Prior treatment with HER2-targeted agents
Untreated central nervous system (CNS) metastases, symptomatic CNS metastases, or radiation treatment for CNS metastases within 4 weeks of start of study treatment. Stable, treated brain metastases are allowed (defined as subjects who are off steroids and anticonvulsants and are neurologically stable with no evidence of radiographic progression for at least 4 weeks at the time of screening)
Known leptomeningeal disease (LMD). If LMD has been reported radiographically on baseline MRI, but is not suspected clinically by the investigator, the subject must be free of neurological symptoms of LMD
Concurrent uncontrolled or active hepatobiliary disorders or untreated or ongoing complications after laparoscopic procedures or stent placement, including but not limited to active cholangitis, unresolved biliary obstruction, infected biloma or abscess. Any complications must be resolved more than 2 weeks prior to the first dose of ZW25
Prior or concurrent malignancy whose natural history or treatment has, in the opinion of the investigator or medical monitor, the potential to interfere with the safety or efficacy assessment of the investigational regimen
Active hepatitis
Infection with human immunodeficiency virus (HIV)-1 or HIV-2
QTc Fridericia (QTcF) > 470 ms
History of myocardial infarction or unstable angina within 6 months prior to enrollment, troponin levels consistent with myocardial infarction, or clinically significant cardiac disease
Acute or chronic uncontrolled pancreatitis or Child-Pugh Class C liver disease
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