Conjunctival Autograft or Limbal Conjunctival Autograft for Recurrent Pterygium Using Mitomycin C

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    Sun Yat-sen University
Updated on 24 January 2021


The purpose of this randomized clinical trial is to compare the efficacy and safety of intraoperative mitomycin C(MMC) combined with limbal conjunctival autograft(LCAG) or conjunctival autograft(CAG) for recurrent pterygium surgery. The investigators will also evaluate particular risk factors related to pterygium recurrence


Intraoperative mitomycin C after pterygium excision is widely used to prevent recurrce of recurrent pterygium. Conjunctival autograft with or without limbal tissue used to cover the bare sclera will efficiently reduce postoperative longstanding epithelial defect.

Patients with recurrent pterygium will be randomly assigned to undertake pterygium excision followed by intraoperative mitomycin C with conjunctival autograft or limbal conjunctival autograft .The patients will be followed at least 12 months. Corneal recurrence is considered as a fibrovascular ingrowth beyond the limbus with conjunctival drag in the area of previous pterygium excision.

Condition Recurrent Pterygium
Treatment Limbal conjunctival autograft, Pterygium Excision, Intraoperative mitomycin C, Conjunctival autograft
Clinical Study IdentifierNCT04463901
SponsorSun Yat-sen University
Last Modified on24 January 2021


Yes No Not Sure

Inclusion Criteria

Recurrent pterygium
Willingness to participate in research project and to attend research time
At least 6 months after last pterygium surgery

Exclusion Criteria

Pregnant,breast-feeding women or poor general health
Patients with significant ocular or lid pathology, such as Sjogren's Syndrome ,infection, exposure keratitis,glaucoma and trauma
Patients with allergy to mitomycin C,tobramycin or local anesthetics
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