Establishment of a Prospective Clinical-biological Database

  • End date
    Nov 14, 2027
  • participants needed
  • sponsor
    Institut du Cancer de Montpellier - Val d'Aurelle
Updated on 14 November 2021


A Clinical and Biological Database will provide to the scientific community a collection of blood and tissues with clinical data to improve knowledge about cancer and help to develope new cancer treatments. This database is specific to Sarcoma


Liposarcomas (LPS) are soft tissue tumours of mesenchymal origin. The most common histological subtypes, represented by well differenciated Lipsarcomas (WD-LPS) and dedifferenciated (DD-LPS), are characterized by the quasi-systematic amplification of the q13-15 of chromosome 12 containing the Mdm2 gene.

The systematic amplification of the Mdm2 gene is such that it is used clinically to distinguish WD/DD-LPS from other types of sarcomas. These observations raise key questions about the high selection pressure that leads to the almost systematic amplification of Mdm2 during the development of these LPS.

Mdm2 is an oncoprotein whose roles in p53 tumour suppressor degradation are broadly described. However, the different inhibitors targeting this interaction were disappointing in clinical trials.

Recently a team from the U1194 INSERM unit of the IRCM which collaborates in this project showed by a pan-genomics analysis, that Mdm2 is recruited to chromatin within a multiproteic complex having as target a transcriptional program involved in the metabolism and in particular in the biosynthesis of the serin.

This clinical-biological basis will allow the continuation of this research project on liposarcomas and the development of new research projects on other histological types of sarcomas.

Condition Sarcoma, All Solid Tumors, Soft Tissue Sarcoma, Solid Tumors, soft tissue sarcomas, Connective and Soft Tissue Neoplasm, sarcomas, Sarcoma (Pediatric)
Treatment Blood sample, Paraffin tissue samples
Clinical Study IdentifierNCT04458792
SponsorInstitut du Cancer de Montpellier - Val d'Aurelle
Last Modified on14 November 2021


Yes No Not Sure

Inclusion Criteria

men or women > 18 years
Patient treated by surgery for : a primitive sarcoma and/or local relapse sarcoma and/or metastatic localisation of sarcoma
patient accepted blood sample
patient treated by radiotherapy before or after the surgery
Patient signed informed consent

Exclusion Criteria

Patient not affiliated to french Social Protection system
Patient under guardianship
Patient unable to understand or comply with study instructions or requirements for psychological, family, social or geographical reasons
Pregnancy and/or feeding
Patient take care in an Emergency Situation
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