Effect of Preoperative Intervention With Folic Acid and Vitamin B12 on Postoperative Neurobehavioral Changes in Children

  • STATUS
    Recruiting
  • End date
    Jun 30, 2025
  • participants needed
    360
  • sponsor
    Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Updated on 24 January 2021
anesthesia
postoperative delirium

Summary

Comparison of preoperative folic acid and VitB12 intervention on postoperative delirium and long-term neurobehavioral changes in children under general anesthesia

Description

Folic acid, as a one-carbon unit transferase coenzyme, participates in the synthesis of purine and thymine, and is an important element of the nervous system. Vitamin B12 participates in methyl conversion and folate metabolism in the body, promoting the conversion of 5-methyltetrahydrofolate to tetrahydrofolate. It has been reported that the lack of serum folic acid and B12 is associated with an increased risk of cognitive impairment. The explanation mechanism of the relationship between folic acid deficiency and cognitive dysfunction may be that folic acid deficiency leads to impaired central nervous system methylation, resulting in insufficient methyl synthesis of myelin sheaths, neurotransmitters, membrane phospholipids and deoxyribonucleic acid. Our previous studies showed that preoperative folic acid supplementation can alleviate myelin damage and cognitive impairment in young rats caused by sevoflurane anesthesia. Therefore, this study further explored the preoperative folic acid and coenzyme B12 supplementation for children's delirium and long-term neurobehavioral changes after general anesthesia.

Details
Condition Delirium
Treatment Folic acid and vitamin B12, brown sugar aqueous
Clinical Study IdentifierNCT04456985
SponsorShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

ASA grade is ~
Children aged 6 months to 2 years old
It is planned to undergo head, neck and maxillofacial surgery under general anesthesia with anesthesia for less than 6 hours

Exclusion Criteria

Children with a history of respiratory tract infection within 1 week
Children with congenital malformations such as congenital heart disease
Children with central nervous system diseases or mental disorders or mental disorders
Children with long-term use of sedative or analgesic drugs
Children with severe liver and kidney dysfunction
Received folic acid and VitB12 supplement treatment or taken related derivatives
Have taken drugs that affect absorption within the past month, such as sulfonamides, aspirin, etc
Those who have participated in other relevant clinical research in the past 3 months
Children with stunting
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