Comparison of the Euploid Rate of Blastocyst Between PPOS and GnRH Antagonist Protocol in Patients Undergoing PGT-A

  • STATUS
    Recruiting
  • End date
    Dec 1, 2022
  • participants needed
    400
  • sponsor
    ShangHai Ji Ai Genetics & IVF Institute
Updated on 24 January 2021

Summary

This randomized trial aims to compare the euploid rate of blastocysts between PPOS and GnRH antagonist protocols in patients undergoing PGT-A. Infertile women who have medical indication for PGT-A will be recruited for study after explanation and counseling if they fulfill the inclusion criteria and do not have the exclusion criteria. Eligible women will be randomised into one of the two groups:

Antagonist group: Women will receive antagonist once subcutaneously daily from day 6 of ovarian stimulation till the day of the ovulation trigger.

PPOS group: Women will receive oral Duphaston 10mg bd from Day 3 till the day of ovulation trigger.

The primary outcome is the euploidy rate of blastocysts.

Details
Condition GnRH Antagonist, Preimplantation Genetic Testing, Progestin-primed Ovarian Stimulation, Euploid Rate, Progestin-primed Ovarian Stimulation, gonadotropin releasing hormone antagonist, Progestin-primed Ovarian Stimulation
Treatment GnRH antagonist, oral Duphaston
Clinical Study IdentifierNCT04414748
SponsorShangHai Ji Ai Genetics & IVF Institute
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age of women <43 years at the time of ovarian stimulation for IVF
Antral follicle count (AFC) >=5 on day 2-5 of the period
PGT-A indicated for advanced maternal age (>=38 years), recurrent miscarriage (>=2 consecutive miscarriage) and repeated implantation failure (>=4 embryos replaced or >=2 blastocysts replaced without success), recurrent foetal aneuploidy

Exclusion Criteria

Presence of a functional ovarian cyst with E2>100 pg/mL
Recipient of oocyte donation
Presence of hydrosalpinx or endometrial polyp which is not surgically treated
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