Study on the Recovery of Pulmonary Function Chest CT Hematologic and Immune & Inflammatory Conditions in COVID-19 Rehabilitation Patients

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  • participants needed
  • sponsor
    Wuhan Union Hospital, China
Updated on 25 January 2021
chest ct
coronavirus infection


The intent of this study was to examine the recovery of individuals who had been hospitalized for COVID-19 in the year following their discharge from the hospital. Parameters studied included serum levels of SARS coronavirus 2 (SARS-CoV 2) IgG antibody, tests of lung function, and imaging data to evaluate changes in lung fibrosis. In addition, we explored the systematic Immune & Inflammation in some of the individuals recovering from COVID-19.


About 20% of COVID-19 developed into a critical illness and about 2% died. The global epidemic continues to develop, but some patients in China have entered the rehabilitation period, which is accompanied by a large number of respiratory symptoms and pulmonary fibrosis, bringing serious harm to the country. Therefore, early accurate detection and prediction of the development trend of patients in rehabilitation period and targeted treatment measures for corresponding patients are the key to the success of COVID-19 rehabilitation period. It will play a key role in the stratified management of the post-epidemic situation, which is crucial to improve the quality of life of COVID-19 patients. We aim to explore the clinical characteristics of rehabilitation patients by detecting some indicators of patients in rehabilitation period, including serum IgG and IgM antibody of SARS-CoV 2, pulmonary function, chest CT imaging, systematic Immune & Inflammation states.

Condition *COVID-19, Covid-19
Clinical Study IdentifierNCT04456101
SponsorWuhan Union Hospital, China
Last Modified on25 January 2021


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Inclusion Criteria

Inpatients recovering from severe/critical COVID-19, or asymptomatic COVID-19 patients with laboratory test for SRARS-COV2 turning negative,or healthy volunteers without COVID-19
The age range is 18-80 years
Subjects or their family members agree to participate in the study and sign informed consent
The previously diagnosed inpatients have been cured and discharged from hospital for about 3 months
without other underlying lung diseases

Exclusion Criteria

Woman who is breastfeeding, pregnant, or preparing to become pregnant
Patients with other underlying lung diseases
Patients with cognitive impairment or poor compliance as determined by the investigator
Participants in other clinical trials within three months
Subjects who were not suitable for clinical trials determined by the investigator
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