LiverMultiScan Analysis of MRI Scans in HCC

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    30
  • sponsor
    National Cancer Centre, Singapore
Updated on 24 January 2021
platelet count
liver cancer
renal function
cancer
tyrosine
systemic therapy
hepatitis
cirrhosis
metastasis
neutrophil count
TACE
alpha fetoprotein
primary liver cancer

Summary

This project is a pilot study to interrogate the potential of LMS as a predictive tool for the selection of therapy for HCC patients. The reliability of LMS to predict patients' response following HCC therapy will leverage on an algorithm that is built from the pool of MRI scans from HCC patients pre- and post-treatment. In the study, MRI scans of 30 HCC and metastatic colorectal cancer (CM) patients (ratio of 4:1) will be analysed. CM cancer patients include patients whose cancers metastasized from colorectal cancer or primary liver cancer. These patients will either receive one of the treatment, surgical resection, Y90 or systemic therapy. A total of 4 MRI scans will be taken for each patient; the first MRI scan will be taken within a month before treatment initiation and the remaining MRI scans will be taken at the 1st, 3rd and 9th month post-initiation of treatment.

Description

Liver cancer is currently the second most common cause of cancer-related death worldwide, and hepatocellular carcinoma (HCC) accounts for more than 90% of liver cancers. There has been a marked increase in HCC-related annual death rates over the past two decades, with the majority of all cases of HCC worldwide found in the Asia-Pacific region. As such, HCC represents a major public health problem in the Asia-Pacific region and globally. There are a significant number of variables known to influence the prognosis of HCC, with the stage of underlying liver disease being a dominant factor. Elucidating these variables remains a challenge and the poor understanding of these variables has translated to poor prognostication of treatment outcomes. To date, no ideal predictive modality has been developed. One of the treatment therapies in HCC is surgical resection. Despite advances in the surgical and perioperative fields, potential posthepatectomy liver failure (PHLF) persists as a life-threatening complication, and is reported in up to 15% of patients (Aliza et al., 2017). This accentuates the need to develop accurate methods to quantitatively characterize future liver remnants (FLR) prior to surgery, as postoperative outcomes mainly depend on the size and quality of FLR (Cieslak et al., 2014).

This study seeks to address this unmet need as we will employ the LMS platform to assess and monitor changes in the liver health of HCC patients following treatment. In addition, this platform will be leveraged upon to monitor patients' response to the different treatment modalities such as surgical resection, Y90 and systemic therapy. These aims will be achieved through the quantitative characterization of liver tissues, which forms the basis of LMS technology. LMS is an MRI-based non-invasive tool that has attained CE marking and FDA clearance to aid the diagnosis of patients with liver disease. This technology is highly sensitive to subtle differences in liver tissue composition and samples the entire liver quickly, rendering it an ideal platform for liver tissue characterisation. LMS uses MRI mapping techniques to characterize liver tissue at the cellular level, delivering the quantification of liver fat and correlates of fibroinflammation and iron load using proton density fat fraction (PDFF), T1 and T2* maps, respectively. The modelling algorithms of this device correct the T1 map (cT1) for the confounding effect of iron overload. In addition, this platform has further refined the measurements for PDFF to be more accurate in liver tissue characterisation. Previously, the use of LMS to predict clinical outcomes through tissue characterisation has been validated in a few clinical studies on patients with liver disease. In a prospective general hepatology clinical cohort following 112 patients for a median of 27 months, patients with higher cT1 values tended to experience clinical events, whereas patients with normal or low cT1 values had no clinical events (Pavlides et al., 2016). Additionally, from a prospective study on 71 patients with suspected non-alcoholic fatty liver disease (NAFLD), cT1 values have been shown to correlated with cirrhosis, ballooning and significant NAFLD (Pavlides et al., 2016). Finally, an independent study has also demonstrated the utility of T1 mapping in predicting clinical outcomes and for distinguishing decompensated cirrhotics from compensated cirrhotics (Bradley, 2018).

In-depth characterisation of liver tissues will be done following Couinaud segmentation of the liver. Specific to the surgical resection cohort, estimated FLR volume and cT1 will be combined to refine the LMS platform in the assessment of liver health. The significance of this in the long term resides in more accurate assessment of surgical risks, which is paramount to improve the care of HCC patients considered for surgical resection. By adopting the LMS platform to monitor patients' response to treatment longitudinally through the characterisation of their liver tissues, our study also seeks to discern features present in the LMS platform that are predictive of patients' outcomes. Additionally, this study will compare anonymized blood test results and anonymized histological reports (histological reports only for the surgical resection cohort) against features observed in the LMS platform to better discern features indicative of patients' outcomes.

This study will monitor patients closely before treatment and after their treatment with follow-up visits, and the MRI scans of these patients across these visits will be analysed using the LMS. A total of 4 MRI scans will be taken for each patient with 1st MRI scan taken within 6 weeks before treatment and the remaining MRI scans taken at the 1st, 3rd and 9th month post-initiation of treatment.

Details
Condition Adenocarcinoma, Malignant Adenoma, Adenocarcinoma, HEPATIC NEOPLASM, Liver Cancer, HEPATOCELLULAR CARCINOMA, Liver Cancer, Malignant Adenoma, liver cell carcinoma
Treatment radiation therapy, Surgery, Drug Treatment
Clinical Study IdentifierNCT04451603
SponsorNational Cancer Centre, Singapore
Last Modified on24 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Common Inclusion Criteria (Surgical Resection, Y90 Treatment and Systemic
Therapy)
Male and female patients, 21 to 90 years of age at the time of signing of the informed consent form
For HCC patients: Diagnosis of HCC confirmed by either 1 of the following 3 criteria
AASLD imaging criteria
Histology/cytology of biopsy or surgically resected tumor tissue samples
Space occupying lesion in the liver and serum alpha-fetoprotein (AFP) of more than 400 in patients with chronic viral hepatitis or cirrhosis of any cause
For CM patients: Diagnosis of colorectal cancer with metastasis to the liver confirmed by histology/cytology
Has ECOG performance status 0-1 before treatment intervention
Inclusion Criteria Specific to Treatment Arm
Surgical Resection
Has received no anti-cancer specific treatment for HCC i.e. previous liver resection, loco-regional therapy (e.g. RFA, TACE, SIRT), radiotherapy, immunotherapy, chemotherapy or neo-adjuvant chemotherapy within 4 weeks prior to the date of the planned surgery
Has adequate bone-marrow reserve, renal function and hepatic function as assessed by standard laboratory criteria
Absolute neutrophil count 1.0 x 10^9/L
Platelet count 50 x 10^9/L
Haemoglobin 9.0 g/dL
INR 2.0
Serum creatinine 1.5 times the Upper Limit of Normal (ULN)
Albumin 2.5 g/dL
Total bilirubin 1.5 times the ULN
Alanine transaminase (ALT) 2.5 times the ULN
Aspartate Transaminase (AST) 2.5 times the ULN
Has Child-Pugh score 7
Y90 treatment
Y-90 therapy as the main treatment
Has Child-Pugh score 7
Systemic therapy
Systemic therapy as the only treatment
Has Child-Pugh score 8

Exclusion Criteria

Common Exclusion Criteria (Surgical Resection, Y90 Treatment and Systemic
Therapy)
Has low creatinine clearance (estimated glomerular filtration rates < 60)
Is unable to return for follow-up visits to monitor for disease response/progression
Is unable to have a MRI scan, including but not limited to claustrophobia, implanted metallic devices and metal foreign bodies
Non-provision of informed consent
For female patients: pregnant or lactating
Exclusion Criteria Specific to Treatment Arm
Surgical resection
Has encephalopathy
Has received a major organ allograft
Has an uncontrolled bleeding disorder
Has uncontrolled congestive heart failure or hypertension, unstable heart disease (coronary artery disease or myocardial infarction) or uncontrolled arrhythmia at the time of enrolment
Has psychiatric or addictive disorders that may compromise his/her ability to give informed consent, or to comply with the study procedures
Has other concurrent severe medical problems, unrelated to the malignancy, that would significantly limit full compliance with the study or expose the patient to unacceptable risk
Y90 treatment
Nil
Systemic therapy
Receiving concurrent therapy alongside systemic therapy
Has no anti-cancer specific treatment within 4 weeks prior to the initiation of systemic therapy
Has encephalopathy
Has history of allergic disease or reactions likely to be exacerbated by any component of treatment
Has had a solid organ or hematologic transplant. Has clinically apparent ascites on physical examination. Note: Ascites detectable on imaging studies only are allowed
Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis
Has active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Note: Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment
Has current pneumonitis or known history of, or any evidence of active, non-infectious pneumonitis that requires steroids
Has uncontrolled congestive heart failure or hypertension, unstable heart disease (coronary artery disease or myocardial infarction) or any uncontrolled arrhythmia at the time of enrolment into study
Has known psychiatric or addictive disorders that may compromise the patient's ability to give informed consent, or to comply with trial procedures
Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial
Has had a minor surgery 7 days prior to the first dose of systemic therapy
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