Outcome in Patients Treated With Intraarterial Thrombectomy - optiMAL Blood Pressure Control (OPTIMAL-BP)

  • STATUS
    Recruiting
  • End date
    Dec 18, 2024
  • participants needed
    668
  • sponsor
    Yonsei University
Updated on 22 August 2021
hypertension
stroke
ischemia
thrombectomy
cerebral infarction
arterial occlusion
intracerebral hemorrhage

Summary

Recent endovascular thrombectomy (EVT) trial have proven the effectiveness of intraarterial revascularization in patients with larger cerebral artery occlusion. The success rate of EVT is close to 80%, but only 50% of patients improve to independent functional outcome. Therefore, new treatment strategies are needed to reduce the futile revascularization. However, updated guidelines recommend the indications for EVT based on the results of randomized clinical trials (RCT), management of post-revascularization is largely unknown.

Current guidelines suggest that systolic blood pressure should be adjusted below 180 mmHg and diastolic blood pressure below 105 mmHg in patients undergoing intraarterial reopening. However, in the case of successful recanalization by EVT, same guideline is adopted even though the possibility of intracerebral hemorrhage or reperfusion injury by high blood pressure. On the other hand, too low blood pressure can worsen cerebral ischemia.

Therefore, this study will compare the effectiveness of active blood pressure control group (with less than 140 mmHg systolic blood pressure) versus standard blood pressure control group (with less than 180 mmHg systolic blood pressure) during the first 24 hours in patients who underwent EVT and achieved successful recanalization (TICI 2b-3). The goal is to reach the target blood pressure within 60 minutes of randomization.

Description

  1. The study is a multicenter, prospective, randomized, open-label trial with blinded end-point assessment (PROBE) design study.
  2. After successful revascularization, the active blood pressure control group and the standard blood pressure control group will be randomized by 1: 1.
  3. Patients who is admitted to the Department of Neurology at the participating hospital with acute cerebral infarction will will be included for 5 years from December 2019 to December 2023 (based on the date of stroke). Patients who have undergone intraarterial thrombectomy and have successfully reopened arteries should be enrolled.
  4. Collect medical history, laboratory findings and blood pressure parameters (systolic blood pressure, diastolic blood pressure, blood pressure variability, etc.), neurological scores, functional recovery, and quality of life indicators.
  5. Neurological scores, functional recovery scores, and quality of life indicators are performed by independent researchers in the blind state.
  6. All data is collected using e-CRF, and the image study will be anonymized and sent to the central adjudication.
  7. Central adjudication will review the image study.
  8. One intermediate analysis will be conducted at the end of first period or when a half of study patients were enrolled.

Details
Condition Ischemic Stroke
Treatment conventional blood pressure control (labetalol, nicardipine), intensive blood pressure control (labetalol, nicardipine)
Clinical Study IdentifierNCT04205305
SponsorYonsei University
Last Modified on22 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 20 years, 95 years old
Acute ischemic stroke patients who underwent intraarterial treatment for large vessel occlusion. (ICA, MCA M1 or M2, ACA A1, PCA P1)
Patients with successful recanalization after intraarterial thrombectomy (TICI 2b or TICI 3)
Patients with an average blood pressure 140 mmHg measured twice within 2 hours of successful recanalization

Exclusion Criteria

Age <20 or >95 years old
Patients with contraindication for use antihypertensive medication after intraarterial thrombectomy
Patients with blood pressure <140 mmHg after successful recanalization
No informed consents from patients
Patients with symptomatic intracranial hemorrhage after successful recanalization
Patients with pre-morbid neurological dysfunction (modified Rankin Scale, mRS >2)
Patients with severe medical and surgical diseases
Patients who are considered having a difficulty to enrollment
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