A Multicenter, Randomized, Flexible-dose, Double-blind Trial of Brexpiprazole Versus Placebo for the Treatment of Adults With Borderline Personality Disorder

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Updated on 9 September 2020


Brexpiprazole is a drug being studied as a possible treatment for borderline personality disorder (BPD).  It was first approved in the United States (10 July 2015) for the treatment of schizophrenia and as an adjunctive therapy (add-on therapy) to antidepressants for the treatment of major depressive disorder. The reason for this study is to find out about the potential benefits and safety of brexpiprazole in subjects with a diagnosis of BPD.

Condition Borderline Personality Disorder, Mood Disorders
Clinical Study IdentifierTX247004
Last Modified on9 September 2020


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Inclusion Criteria

Is your age between 18 yrs and 65 yrs?
Gender: Male or Female
Do you have any of these conditions: Borderline Personality Disorder or Mood Disorders?
Must have a primary diagnosis of Borderline Personality Disorder (it does not have to have been previously diagnosed)
Sexually active adults must agree to use birth control
You must not have a diagnosis of Bipolar Disorder, Antisocial Personality Disorder, Eating Disorder or Schizophrenia
Must not have uncontrolled thyroid disorder or any history of heart attack or congestive heart failure
Must not have HIV or Hepatitis B or C
Must not have previously taken Brexpiprazole (Rexulti)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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