Detection of Herpesvirus DNA (CMV, EBV, HHV-6 and HSV) in Colonic Tissue: Impact on Ulcerative Colitis Flare-up (VIRCH)

  • STATUS
    Recruiting
  • End date
    Jun 28, 2025
  • participants needed
    100
  • sponsor
    Centre Hospitalier Universitaire de Saint Etienne
Updated on 28 October 2022
monoclonal antibodies
immunosuppressive agents
tumor necrosis factor
tumor necrosis factor alpha
tumour necrosis
anti-tnf-alpha therapy

Summary

Flare-up of ulcerative colitis (UC) is characterized by the inflammation of colon mucosa that requires the use of immunosuppressive therapies. In previous studies, the active role of cytomegalovirus (CMV) has been demonstrated, with a correlation between the cytomegalovirus DNA ((deoxyribonucleic acid) load in the inflamed tissue and the resistance to successive lines of immunosuppressive therapy (Roblin et al., Am J Gastroenterol 2011). The main aim of this monocentric prospective study is to evaluate the DNA viral load by qPCR (Polymerase Chain Reaction) of 3 herpesviruses (Epstein-Barr virus, herpes virus 6 and herpes simplex) together with that of CMV in colonic mucosa depending of the local inflammation (endoscopically normal region, inflamed mucosa or ulcer) in patients suffering of moderate to severe UC flare-up (Mayo score >6 with endoscopic score higher or equal than 2). The viral load will also be correlated to the Mayo endoscopic score and the response to immunosuppressive drugs (steroid and anti-TNF (Tumor Necrosis Factor) monoclonal antibodies).

Details
Condition Colitis, Ulcerative
Treatment Blood sample, Biopsies, Rectosigmoidoscopy
Clinical Study IdentifierNCT03172195
SponsorCentre Hospitalier Universitaire de Saint Etienne
Last Modified on28 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age>18 years
Voluntary to participate to the study
Flare-up of ulcerative colitis with Mayo score >6
Ability to receive steroid or anti-TNF therapy
Agree the rectosigmoidoscopy and the therapies

Exclusion Criteria

Age <18 years
Pregnancy
Disagree the rectosigmoidoscopy or the therapies
Participation to the evaluation of a new therapy
Colectomy (partial or total)
Contraindication of steroid or anti-TNF therapy
Anticoagulant drugs
Clear my responses

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