Dual-scopic Pancreatic Necrosectomy (DPN)

  • End date
    Dec 31, 2025
  • participants needed
  • sponsor
    First People's Hospital of Hangzhou
Updated on 25 January 2021
ct scan
abdominal pain
serum amylase level
abdominal ct scan


The LPN procedure is performed under general anesthesia. The transperitoneal access to peripancreatic space is via the gastro-colic ligament and greater omentum, effusion and pus is removed by laparoscopic forceps and suction. Laparoscopic cholecystectomy (LC) is performed during the LPN procedure on patients with indication.

The NPN procedure is followed by the standard retroperitoneal approach. After the catheter is exchanged over a guide wire and serially dilated up from 6F to 24F followed by Seldinger technique, the access track to the necrotic cavity is established. A nephroscope is inserted into the cavity through the track for debridement. Using forceps and suction, the peripancreatic solid necrotic tissue and pus is grasped and removed. A large-bore irrigating drain is left in the cavity, with continuous irrigation by warm normal saline solution at a rate of 100-125 ml/h after surgery.

Condition Pancreatitis, Pancreatitis, Pancreatic disorder, Pancreatic Disorders, Necrotizing pancreatitis, Pancreatic Disorders
Treatment Dual-scopic pancreatic necrosectomy(DPN)
Clinical Study IdentifierNCT04443595
SponsorFirst People's Hospital of Hangzhou
Last Modified on25 January 2021


Yes No Not Sure

Inclusion Criteria

All patients ages 18 or above admitted to UPMC with a diagnosis of AP based on at least 2 of the following criteria:(i) abdominal pain characteristic of AP (ii) serum amylase and/or lipase 3 times the upper limit of normal (iii) characteristic findings of AP on abdominal CT scan will be screened for study enrollment

Exclusion Criteria

Less than 18 years of age
Pregnant women
Presence of renal dysfunction (Cr>1.5mg/dL)
Pre existing heart dysfunction or NYHA classification score above III
Coagulation disorder
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