Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection

  • End date
    Jul 17, 2023
  • participants needed
  • sponsor
    Chinese Medical Association
Updated on 25 January 2021


Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.

Condition Family, Aneurysm, Aneurysm, Aortic Dissection, Aortic Dissection, Familial, With or Without Aortic Aneurysm, Aortic Dissection, Familial, With or Without Aortic Aneurysm, Aortic Dissection, Familial, With or Without Aortic Aneurysm
Treatment movement, movement
Clinical Study IdentifierNCT04439565
SponsorChinese Medical Association
Last Modified on25 January 2021


Yes No Not Sure

Inclusion Criteria

Family inclusion criteria: 1 at least one person in each generation of a family has aortic dissection, and at least two generations of members can be included

Exclusion Criteria

Pedigree exclusion criteria: pedigree members have marfan syndrome, Loeys-Dietz syndrome, Ehler-Danlos syndrome, aneurysm-Osteoarthritis syndrome and other syndroms
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