Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

  • STATUS
    Recruiting
  • End date
    Jan 1, 2023
  • participants needed
    160
  • sponsor
    University of Minnesota
Updated on 6 October 2021
estrogen
blood test
progesterone
testosterone
follicle stimulating hormone
premature menopause
sensitivity testing
Accepts healthy volunteers

Summary

This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (49 yr old) and older (50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.

Description

Aim One: Determine mechanisms driving autonomic dysregulation of blood pressure (BP) in premature and early menopausal women. Because sympathetic activity and baroreflex function are important contributors for autonomic support of BP regulation, these two mechanisms will be assessed in premature and early menopausal women who are 49 yr old. To specifically identify the influence of menopause, these women will be compared to age-matched premenopausal women. The primary hypothesis is that there is greater resting sympathetic activity and blunted baroreflex function in premature and early menopausal women compared with age-matched premenopausal women. The secondary hypothesis is that BP and sympathetic reactivity will be greater in premature and early menopausal compared with age-matched premenopausal women when the sympathetic nervous system is challenged with a stressor.

Aim Two: Determine mechanisms driving autonomic dysregulation of BP in older menopausal women. Because older age contributes to risk of CVD, it is imperative to assess the long-term effects of premature and early menopause in older (50 yr) women. To determine the impact of the premature loss of sex hormones on cardiovascular physiology, women whom have lived without functioning ovaries for >10 yr will be compared to age-matched women who entered menopause at a typical age. The primary hypothesis is that resting sympathetic activity is greater and baroreflex function is attenuated in women who experience premature or early menopause compared with typically-aged menopausal women. The secondary hypothesis is that BP and sympathetic reactivity will be greater in premature and early compared with typically-aged menopausal women when the sympathetic nervous system is challenged with a stressor.

Details
Condition early menopause, Premature ovarian failure, Premature Menopause, arterial hypertension, Elevated Blood Pressure, high blood pressure, Hypertension, Blood pressure, High Blood Pressure (Hypertension), Menopause, Vascular Diseases, Blood Pressure, High Blood Pressure (Hypertension - Pediatric), Diabetes and Hypertension
Treatment blood tests, Microneurography to measure muscle sympathetic nerve activity (MSNA), Baroreflex sensitivity testing, Sympathoexcitatory Maneuvers
Clinical Study IdentifierNCT04439370
SponsorUniversity of Minnesota
Last Modified on6 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Aged 35-49 or 50-70 years of age who experienced premature (<40) or early (45) menopause
Premenopausal 35-49 years of age
Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old
Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of >30 mIU/mL

Exclusion Criteria

Current nicotine/tobacco use within the past six months
Are diabetic or asthmatic
Have diagnosed significant carotid stenosis
Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury
Have existing metabolic or endocrine abnormities
Take any heart/blood pressure medications that are determined to interfere with study outcomes
IF the participant is premenopausal AND currently taking OC or other exogenous steroids that are determined to interfere with study outcomes
Females who classify as having early or premature menopause AND are not willing to discontinue OC or MHT in order to complete the study
Are pregnant or breastfeeding
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