Plasma Radiofrequency Ablation at Low Temperature Versus Electrocautery Block Resection at High Frequency for Localized Recurrent Nasopharyngeal Carcinoma

  • End date
    May 25, 2025
  • participants needed
  • sponsor
    Sun Yat-sen University
Updated on 25 January 2021


This study aims at exploring whether plasma radiofrequency ablation at low temperature is associated with better survival outcome in localized recurrent nasopharyngeal carcinoma by conducting a randomized controlled trial of plasma radiofrequency ablation at low temperature versus electrocautery block resection at high frequency for localized recurrent nasopharyngeal carcinoma. If the hypothesis is confirmed, it is expected to provide a convenient choice for the surgical treatment of localized recurrent nasopharyngeal carcinoma.

Condition Surgery, Surgical aspects, Surgery, Recurrent Nasopharyngeal Carcinoma, surgical procedures, surgical treatment, surgeries, surgical procedure
Treatment Plasma radiofrequency ablation, Electrocautery block resection
Clinical Study IdentifierNCT04425265
SponsorSun Yat-sen University
Last Modified on25 January 2021


Yes No Not Sure

Inclusion Criteria

At least 6 months disease free interval (defined as duration between the initial course of radiotherapy and recurrence)
Histopathologically diagnosed with undifferentiated or differentiated, nonkeratinizing nasopharyngeal carcinoma
Resectable recurrent nasopharyngeal carcinoma
recurrent T1N0M0 according to the American Joint Committee on Cancer (AJCC) 8th staging B) recurrent T2N0M0(the tumor was confined to the surface of the parapharyngeal space and was more than 0.5cm away from the internal carotid artery) according to the American Joint Committee on Cancer (AJCC) 8th staging
Age: 18-70 years old
Subjects must sign an informed consent form

Exclusion Criteria

Karnofsky score (KPS)70
Has known Subjects with other malignant tumors
Has seriously mental disease
Uncontrolled clinically significant heart disease and Pulmonary dysfunction
Pregnancy or breast feeding
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