Infigratinib in Recurrent High-Grade Glioma Patients

  • End date
    Jul 29, 2023
  • participants needed
  • sponsor
    Nader Sanai
Updated on 28 January 2021
renal function
measurable disease
neutrophil count
glioblastoma multiforme
malignant glioma
recurrent glioblastoma
contrast-enhanced magnetic resonance imaging
recurrent malignant glioma
renal function test


This trial is an open-label, multicenter, Phase 0 trial that will enroll up to 20 participants with recurrent high-grade glioma with FGFR1 K656E or FGFR3 K650E mutation or FGFR3-TACC3 translocation which are scheduled for resection. In the lead-in cohort, a total of 20 participants will be enrolled into the proposed phase 0 clinical trial. Participants will be administered infigratinib prior to surgical resection of their tumor.

Condition Glioma, Gliomas, Glioblastoma Multiforme, Glioblastoma Multiforme, Glomerular Basement Membrane, Gliomas, glioblastoma, glial tumor
Treatment Infigratinib
Clinical Study IdentifierNCT04424966
SponsorNader Sanai
Last Modified on28 January 2021


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