Infigratinib in Recurrent High-Grade Glioma Patients

  • STATUS
    Recruiting
  • End date
    Jul 29, 2023
  • participants needed
    20
  • sponsor
    Nader Sanai
Updated on 28 January 2021
renal function
calcium
amylase
measurable disease
lipase
FGFR1
neutrophil count
glioblastoma multiforme
temozolomide
malignant glioma
recurrent glioblastoma
contrast-enhanced magnetic resonance imaging
recurrent malignant glioma
FGFR3
renal function test

Summary

This trial is an open-label, multicenter, Phase 0 trial that will enroll up to 20 participants with recurrent high-grade glioma with FGFR1 K656E or FGFR3 K650E mutation or FGFR3-TACC3 translocation which are scheduled for resection. In the lead-in cohort, a total of 20 participants will be enrolled into the proposed phase 0 clinical trial. Participants will be administered infigratinib prior to surgical resection of their tumor.

Details
Condition Glioma, Glioblastoma Multiforme, Glomerular Basement Membrane, Gliomas, glioblastoma, glial tumor
Treatment Infigratinib
Clinical Study IdentifierNCT04424966
SponsorNader Sanai
Last Modified on28 January 2021

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