Outcome of Patients With Primary Aldosteronism

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    Changi General Hospital
Updated on 22 August 2021
cardiovascular morbidity
essential hypertension


Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally. PA is caused by excessive release of a hormone (aldosterone) from the adrenal glands, which can be unilateral (one gland) or bilateral (both glands).

It has been shown that excess aldosterone has other harmful effects in addition to hypertension, such as directly affecting the heart, blood vessels, kidneys, leading to increased cardiovascular morbidity and mortality. This is supported by studies showing reversal of these effects after treatment for PA.

The investigators aim to assess the long-term cardiovascular, and renal outcomes of patients with PA, compared to patients with essential hypertension.

Condition end stage renal failure, end-stage renal failure, Adrenalectomy; Status, Hyperaldosteronism, Kidney Failure, chronic kidney disease, end-stage renal disease, Mineralocorticoid Excess, Mineralocorticoid Antagonists [Aldosterone Antagonists] Causing Adverse Effects in Therapeutic Use, end stage kidney disease, Hypokalemia, Chronic renal failure, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral), Primary Aldosteronism Due to Aldosterone Producing Adenoma, chronic kidney disease (ckd), conn, chronic renal insufficiency, end stage renal disease, primary hyperaldosteronism, chronic renal disease, Kidney Failure (Pediatric), esrd, Renal Failure, Cardiovascular Morbidity, primary aldosteronism
Treatment Unilateral adrenalectomy in patients with unilateral disease
Clinical Study IdentifierNCT04428827
SponsorChangi General Hospital
Last Modified on22 August 2021


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Inclusion Criteria

Patients with suspected primary aldosteronism

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