PROactive Evaluation of Function to Avoid CardioToxicity

  • End date
    Mar 31, 2022
  • participants needed
  • sponsor
    Washington University School of Medicine
Updated on 8 July 2021
early detection
cancer treatment
cardiac mri


This study is intended to evaluate the ability of an intramyocardial strain analysis package with cardiac MRI to assist in the early detection and management of cardiotoxicity from therapeutics used to treat cancer.

Condition Pulmonary Disease, Connective and Soft Tissue Neoplasm, Multiple Myeloma, Lymphoma, leukemia, Breast Cancer, Lung Neoplasm, Lymphoproliferative Disorder, Lymphoma, Sarcoma, Bronchial Neoplasm, Diet and Nutrition, Chronic Diarrhea, Skin Wounds, Chronic Shoulder Pain, Vaginal Atrophy, Non-Hodgkin's Lymphoma, Adverse Effects, Drugs, Injection Port, Breast Cancer - HER2 Positive, All Solid Tumors, Anal Dysplasia, Primary Immunodeficiency, Pediatric Health, Near-Sighted Corrective Surgery, Solid Tumors, Cardiotoxicity, Peripheral Arterial Occlusive Disease, Breast Cancer Diagnosis, Brain Function, Cardiac Toxicity, Recurrent Respiratory Papillomatosis, Razor Bumps (Pseudofolliculitis Barbae), Leukemia (Pediatric), Sarcoma (Pediatric), Metastatic Triple-Negative Breast Cancer, Lung Cancer, Lung Disease, Soft Tissue Sarcoma, Lymphoproliferative disorders, breast carcinoma, leukemias, sarcomas, soft tissue sarcomas, cancer, breast, lymphomas, multiple myeloma (mm), carcinoma lung, lung carcinoma
Treatment MyoStrain®
Clinical Study IdentifierNCT03862131
SponsorWashington University School of Medicine
Last Modified on8 July 2021


Yes No Not Sure

Inclusion Criteria

Participant in the SURVIVE registry
Signed informed consent form for PROACT
Histological diagnosis of any cancer type (patients with treated and clinically stable brain metastasis are acceptable)
Scheduled to receive anti-cancer therapy (radiation therapy is permitted)

Exclusion Criteria

Contraindication to magnetic resonance imaging (MRI)
Unable to comply with study investigations (in the judgment of the investigator)
Life expectancy less than 1 year
Note: If a patient develops a temporary contraindication (e.g. temporary tissue expanders in breast cancer patients) after the baseline MRI, follow up MRIs will be discontinued for safety for the duration in which the patient has the contraindication. However, once the patient is no longer contraindicated to receiving MRIs, the study schedule may resume with their next scheduled MRI time point from the date of enrollment. Therefore, some time points may be skipped during the patient's enrollment in the study
Also, if a patient needs a repeat MRI at any time point for any reason (i.e
panic attack during the MRI causing them to not be able to continue
unreadable images, etc.), we may repeat the MRI as long as the patient is
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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