Magnetic Resonance Imaging for Detection of Peritoneal Mesothelioma

  • End date
    Jan 22, 2025
  • participants needed
  • sponsor
    University of Chicago
Updated on 27 May 2022
peritoneal mesothelioma


For cancers, such as mesothelioma, that spread to the lining of the stomach, detecting the cancer is very difficult with CT or MRI scans. Researchers at the University of Chicago want to find out if the new experimental MRI and ultrasound imaging techniques do a better job of detecting these cancers. Researchers will use new MRI and ultrasound techniques to see if it can find evidence of cancer that has spread to the lining of the abdomen, and right now these new techniques are only used for research.

Condition Mesothelioma, Peritoneal Mesothelioma
Treatment ultrasound, HR-MRI, Standard CT Imaging
Clinical Study IdentifierNCT03867578
SponsorUniversity of Chicago
Last Modified on27 May 2022


Yes No Not Sure

Inclusion Criteria

18 years old or older
Biopsy-proven MPM
Surgery for PM planned at UCM within 60 days
Able to tolerate CT, MRI, US scans, and surgery
Able to provide written informed consent
For women of child bearing age, ability and willingness to use appropriate contraceptive methods before imaging and for a period of 365 days thereafter

Exclusion Criteria

Pregnancy / Breastfeeding
Allergy or intolerance to iodinated or gadolinum contrast dyes
Contraindications to CT or MRI imaging including chronic kidney disease with GFR <60mL/min/1.73m2
Bioimplants unsuitable for MRI imaging (activated by mechanical, electronic, radiofrequency, or magnetic means), such as cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps
Permanent tattoos or eyeliner with magnetic dyes
Subjects with shrapnel or metal fragments lodged in the body
Anxiety, claustrophobia, or any medical condition that would preclude lying still in an MRI scanner for 1-1.5 hours
Cardiac, circulatory, or perspiration problems leading to impaired thermoregulation
Respiratory or cardiac impairment limiting the ability to lie flat
Inability to breath-hold for MRI acquisition
Vascular or aneurysm clips or any other surgical implant that is not MRI-compatible
Any other ferromagnetic bioimplant that would be damaged by MRI
Mental, cognitive, or mental health impairments that preclude the subject from providing informed consent or adhering to the treatment protocol
Subjects unable to adhere to the protocol or communicate effectively with researchers
Imprisoned subjects
Subjects with history of prior CRS/HIPEC or other peritonectomy surgery that might alter characteristics of the peritoneum
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