Magnetic Resonance Imaging for Detection of Peritoneal Mesothelioma

STATUS

Recruiting
End date

Jan 22, 2025
participants needed

24
sponsor

University of Chicago

Updated on 27 May 2022

See if I qualify

cancer

peritoneal mesothelioma

Summary

For cancers, such as mesothelioma, that spread to the lining of the stomach, detecting the cancer is very difficult with CT or MRI scans. Researchers at the University of Chicago want to find out if the new experimental MRI and ultrasound imaging techniques do a better job of detecting these cancers. Researchers will use new MRI and ultrasound techniques to see if it can find evidence of cancer that has spread to the lining of the abdomen, and right now these new techniques are only used for research.

Details

Condition	Mesothelioma, Peritoneal Mesothelioma
Treatment	ultrasound, HR-MRI, Standard CT Imaging
Clinical Study Identifier	NCT03867578
Sponsor	University of Chicago
Last Modified on	27 May 2022

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	18 years old or older
	Biopsy-proven MPM
	Surgery for PM planned at UCM within 60 days
	Able to tolerate CT, MRI, US scans, and surgery
	Able to provide written informed consent
	For women of child bearing age, ability and willingness to use appropriate contraceptive methods before imaging and for a period of 365 days thereafter
Exclusion Criteria
	Pregnancy / Breastfeeding
	Allergy or intolerance to iodinated or gadolinum contrast dyes
	Contraindications to CT or MRI imaging including chronic kidney disease with GFR <60mL/min/1.73m2
	Bioimplants unsuitable for MRI imaging (activated by mechanical, electronic, radiofrequency, or magnetic means), such as cochlear implants, pacemakers, neurostimulators, biostimulators, electronic infusion pumps
	Permanent tattoos or eyeliner with magnetic dyes
	Subjects with shrapnel or metal fragments lodged in the body
	Anxiety, claustrophobia, or any medical condition that would preclude lying still in an MRI scanner for 1-1.5 hours
	Cardiac, circulatory, or perspiration problems leading to impaired thermoregulation
	Respiratory or cardiac impairment limiting the ability to lie flat
	Inability to breath-hold for MRI acquisition
	Vascular or aneurysm clips or any other surgical implant that is not MRI-compatible
	Any other ferromagnetic bioimplant that would be damaged by MRI
	Mental, cognitive, or mental health impairments that preclude the subject from providing informed consent or adhering to the treatment protocol
	Subjects unable to adhere to the protocol or communicate effectively with researchers
	Imprisoned subjects
	Subjects with history of prior CRS/HIPEC or other peritonectomy surgery that might alter characteristics of the peritoneum

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Magnetic Resonance Imaging for Detection of Peritoneal Mesothelioma