4SCAR-CD44v6 T Cell Therapy Targeting Cancer
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- STATUS
- Recruiting
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- End date
- Dec 31, 2023
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- participants needed
- 100
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- sponsor
- Shenzhen Geno-Immune Medical Institute
Summary
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of 4SCAR-CD44v6 T-cell therapy targeting multiple cancers. The study also aims to learn more about the function of the CD44v6 CAR-T cells and their persistency in the patients.
Description
CD44 variant domain 6 (CD44v6) which belongs to CD44 family has been implicated in tumorigenesis, tumor cell invasion and metastasis. The expression of CD44v6 was reported for the majority of squamous cell carcinomas, a proportion of adenocarcinomas of differing origin, a proportion of melanoma and lymphoma. This expression pattern has made CD44v6 an attractive target for the therapy of various types of CD44v6 positive cancers.
The T cells from patients or transplantation donors will be genetically modified with lentiviral CAR vector to recognize specific molecules - CD44v6 expressed on the surface of the cancer cells. The engineered T cells will be applied to patients through intravenous delivery.
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of CD44v6 CAR-T cell therapy in multiple cancers including - but not limited to - stomach cancer, breast cancer, prostate cancer, multiple myeloma and lymphoma which are CD44v6 positive. Another goal of the study is to learn more about the function of the 4SCAR-CD44v6 T cells and their persistency in the patients.
Details
| Condition | Cancers Which Are CD44v6 Positive |
|---|---|
| Treatment | CD44v6-specific CAR gene-engineered T cells |
| Clinical Study Identifier | NCT04427449 |
| Sponsor | Shenzhen Geno-Immune Medical Institute |
| Last Modified on | 25 January 2021 |
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