Chronic Insomnia and CSF Markers of Dementia - Effects of Treatment

  • End date
    Dec 30, 2021
  • participants needed
  • sponsor
    University of Pennsylvania
Updated on 1 February 2021
behavior therapy
sleep disturbances
cognitive therapy
chronic insomnia


The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasing vulnerability to dementia. Longitudinal studies have found that sleep disturbance often precedes and increases risk for dementia by several years. The purpose of this study is to examine whether treatment of insomnia with cognitive behavioral therapy (CBT-I) is associated with a decrease in dementia biomarkers found in cerebrospinal fluid (CSF). Fifteen adults age 30-50 with chronic insomnia will undergo overnight polysomnography and CSF sampling in the morning. This will be followed by 8 weeks of treatment with CBT-I and then repeat CSF sampling.

Condition Insomnia, chronic insomnia
Treatment cognitive behavioral treatment of insomnia
Clinical Study IdentifierNCT04073992
SponsorUniversity of Pennsylvania
Last Modified on1 February 2021


Yes No Not Sure

Inclusion Criteria

Is your age between 30 yrs and 50 yrs?
Gender: Male or Female
Do you have Insomnia?
Do you have any of these conditions: Insomnia or chronic insomnia?
Age 30-50
Men and women
Meet DSM5 Diagnostic Criteria for insomnia disorder

Exclusion Criteria

Diagnosis or evidence of sleep disorders other than insomnia as determined by the screening questionnaires and clinical history
Women who have been pregnant or lactating within the past six months
Non-fluency in spoken or written English
Current or past month shiftwork defined as working during the evening or night shift
Current use of medications or OTC products that impact sleep
Evidence of neurological abnormalities that could include the risks associated with lumbar puncture (e.g.papilledema, mass lesion, Chiari malformation)
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