This is a Phase 1/2 study of selinexor in combination with standard of care (SoC) therapy for newly diagnosed glioblastoma (nGBM) or recurrent glioblastoma (rGBM). This study will be conducted in 2 phases: a Phase 1a dose finding study followed by Phase 1b (dose expansion) and a Phase 2 randomized efficacy exploration study and will independently evaluate 3 different combination regimens in 3 treatment arms in patients with nGBM (Arms A and B) or with rGBM (Arm C).
| Condition | Glioblastoma Multiforme |
|---|---|
| Treatment | bevacizumab, carmustine, Selinexor, Temozolomide (TMZ), Lomustine (CCNU), Standard Fractionated Radiation therapy (RT), TTField |
| Clinical Study Identifier | NCT04421378 |
| Sponsor | Karyopharm Therapeutics Inc |
| Last Modified on | 8 February 2023 |
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