Lessons on Urethral Lidocaine in Urodynamics

  • End date
    Oct 22, 2022
  • participants needed
  • sponsor
    University of Texas Southwestern Medical Center
Updated on 7 December 2021
brimonidine tartrate ophthalmic solution
water-based vaginal lubricant
urodynamic studies


This trial will assess whether use of intraurethral 2% lidocaine jelly meaningfully impacts sensation during filling (i.e., a change of more than 25% of first sensation, first desire to void, strong desire to void, or maximum cystometric capacity) and determine whether the use of intraurethral 2% lidocaine jelly meaningfully impacts pain/discomfort, filling metrics, and voiding metrics.


This trial is a randomized, double blind, controlled trial for patients undergoing complex cystometric evaluation. Patients will undergo routine complex cystometric evaluation for acquisition of baseline data using a small amount of intraurethral aqueous jelly for catheter lubrication. Then, they will be randomized to instillation of either placebo (additional intraurethral aqueous jelly, 5ml) or intraurethral 2% lidocaine jelly. Participants then undergo complex cystometry a second time. Normal variations in studies with placebo will be compared to variations within the 2% lidocaine jelly group to determine if cystometric parameters are altered in any clinically important ways. Patient discomfort will also be evaluated by both the patient and the urodynamics advanced practice nurse.

Condition Cystocele, Pelvic Floor Disorders, Genital Prolapse, Disorder of uterus NOS, bladder disorder, Ptosis, pelvic organ prolapse, Genitourinary Prolapse, Uterine Disorders, female cystocele, dropped bladder, Uterine Prolapse, cystocoele, vaginal prolapse, Urethra Issue, Pregnancy Complications, Vaginal Vault Prolapse, Bladder Disorders, Urinary Incontinence
Treatment lidocaine topical, Water-Based Vaginal Lubricant
Clinical Study IdentifierNCT04038099
SponsorUniversity of Texas Southwestern Medical Center
Last Modified on7 December 2021


Yes No Not Sure

Inclusion Criteria

Female patients
>18 years of age
Already scheduled (or being scheduled) for UDS to assess urinary incontinence
Able to speak and read in English

Exclusion Criteria

Diagnosis of pelvic pain, interstitial cystitis, or bladder pain syndrome
Known neurogenic disease impacting voiding/ continence (e.g., Parkinson disease, multiple sclerosis, myasthenia gravis, recent stroke)
Active UTI
Pelvic organ prolapse that is unable to be easily reduced
Pregnancy or breastfeeding
Allergy or hypersensitivity to lidocaine or local anesthetics
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