Investigating Otilimab in Patients With Severe Pulmonary COVID-19 Related Disease

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Updated on 23 September 2021
mechanical ventilation
coronavirus infection


OSCAR (Otilimab in Severe COVID-19 Related Disease) is a multi-center, double-blind, randomized, placebo-controlled trial to assess the efficacy and safety of otilimab for the treatment of severe pulmonary COVID-19 related disease. The study is being conducted in 2 parts (Part 1 and Part 2). Otilimab is a human monoclonal anti-granulocyte macrophage colony stimulating factor (GM-CSF) antibody that has not previously been tested in participants with severe pulmonary COVID-19 related disease in Part 1. The aim of this study is to evaluate the benefit-risk of a single infusion of otilimab in the treatment of hospitalized participants with severe COVID-19 related pulmonary disease with new onset hypoxia requiring significant oxygen support or requiring early invasive mechanical ventilation (less than or equal to [<=] 48 hours before dosing). Participants will be randomized to receive a single intravenous (IV) infusion of otilimab or placebo, in addition to standard of care.

Condition Upper respiratory infection, Severe Acute Respiratory Syndrome, Throat and Tonsil Infections, sars, severe acute respiratory syndrome (sars)
Treatment Placebo, Standard of Care, Placebo 2, Placebo 1, Otilimab
Clinical Study IdentifierNCT04376684
Last Modified on23 September 2021

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