Neoadjuvant Gemcitabine Plus Cisplatin With or Without Durvalumab in Resectable Biliary Tract Cancer

  • STATUS
    Recruiting
  • End date
    Dec 30, 2023
  • participants needed
    45
  • sponsor
    Asan Medical Center
Updated on 2 August 2021
malignant disease
cancer
carcinoma
metastasis
pet scan
gemcitabine
carcinoma in situ
durvalumab
adenocarcinoma
cholangiocarcinoma
cisplatin/gemcitabine
gallbladder carcinoma
biliary tract cancer
gemcitabine/cisplatin

Summary

Considering that the poor prognosis of resected biliary tract cancer and negative impact on the survival outcomes of R1/R2 resection, neoadjuvant chemotherapy may improve R0 resection rates and the survival outcomes of patients with resectable biliary tract cancer. The addition of durvalumab to gemcitabine/cisplatin as neoadjuvant chemotherapy may improve the R0 resection rates compared to gemcitabine/cisplatin in patients with localized biliary tract cancer. In this phase 2 trial, a total of 45 patients with localized biliary tract cancer will be 2:1 randomized to durvalumab plus gemcitabine/cisplatin or gemcitabine/cisplatin.

Details
Condition Adenocarcinoma, Cholangiocarcinoma, Biliary neoplasm, Neoplasm of unspecified nature of digestive system, Malignant neoplasm of gallbladder, Gallbladder Disease, Gallbladder Carcinoma, Urothelial Tract Cancer, Gall Bladder Disorders, Malignant Adenoma, Gall Bladder Cancer, Biliary Tract Cancer, Digestive System Neoplasms, gallbladder cancer
Treatment Durvalumab + Gem/Cis, Gem/Cis
Clinical Study IdentifierNCT04308174
SponsorAsan Medical Center
Last Modified on2 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol
Age > 19 years at time of study entry
Histologically confirmed adenocarcinoma of biliary tract (intrahepatic, hilar or extrahepatic cholangiocarcinoma, or gallbladder carcinoma)
Localized, potentially resectable, non-metastatic disease (determined at the discretion of attending surgeons) based on the results of CT, MRI or PET-CT scans
No active uncontrolled infection, except chronic viral hepatitis under antiviral therapy
Eastern Cooperative Oncology Group (ECOG performance status of 0 or 1
Body weight >30kg
Adequate normal organ and marrow function
Patient is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up
No other malignant disease apart from non-melanotic skin cancer, carcinoma in situ of the uterine cervix, localized prostate or papillary thyroid cancer, or any other cancer where treated with curative intent > 5 years previously without evidence of relapse

Exclusion Criteria

Medical or psychiatric conditions that compromise the patient's ability to give informed consent or to complete the protocol or a history of non-compliance
Obstruction of gastrointestinal tract
Active gastrointestinal bleeding
Myocardial infarction within 6 months prior to the study medication, and other clinically significant heart disease (e.g., unstable angina, congestive heart failure or uncontrolled hypertension)
Evidence of severe or uncontrolled systemic disease or any concurrent condition which in the investigator's opinion makes it undesirable for the patient to participate in the study or which would jeopardise compliance with the protocol
Combined hepatocellular carcinoma/cholangiocarcinoma is excluded
History of allogenic organ transplantation
History of another primary malignancy except for
Malignancy treated with curative intent and with no known active disease 5 years before the first dose of IP and of low potential risk for recurrence
Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease
Adequately treated carcinoma in situ without evidence of disease
Mean QT interval corrected for heart rate using Fridericia's formula (QTcF) 470 ms calculated from 3 ECGs (within 15 minutes at 5 minutes apart)
Female patients who are pregnant or breastfeeding or male or female patients of reproductive potential who are not willing to employ effective birth control from screening to 90 days after the last dose of durvalumab monotherapy
Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients
Judgment by the investigator that the patient is unsuitable to participate in the study and the patient is unlikely to comply with study procedures, restrictions and requirements
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