Phase 1 Study of SQ3370 in Patients With Advanced Solid Tumors

  • End date
    Aug 1, 2023
  • participants needed
  • sponsor
    Shasqi, Inc.
Updated on 15 April 2021
Principal Investigator
Primary Contact
Chris O'Brien Lifehouse (2.4 mi away) Contact
+5 other location
primary cancer
solid tumour
solid tumor
metastatic solid tumor
solid neoplasm
metastatic malignant solid tumor


The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of SQ3370 in patients with cancer (solid tumors).

Condition Cancer, Cancer/Tumors, Ewing's Family Tumors, Cancer (Pediatric), Neoplasms, primary cancer, primary malignant neoplasm, malignancy, cancers, malignancies, malignant tumor, malignant tumors
Treatment SQ3370
Clinical Study IdentifierNCT04106492
SponsorShasqi, Inc.
Last Modified on15 April 2021


Yes No Not Sure

Inclusion Criteria

Diagnosis of an advanced local or metastatic solid tumor
Adequate hematologic, hepatic, renal, and coagulation function
Tumor is the type where published clinical data would suggest that anthracyclines have cytotoxic activity

Exclusion Criteria

CHF, severe myocardial insufficiency, or cardiac arrhythmia
Prior exposure to 300 mg/m^2 of Dox HCl or DOXIL / CAELYX or 600 mg/m^2 of Epirubicin HCl
Any of the following within 28 days prior to Cycle 1 Day 1
Major surgery, as defined by the Investigator
Currently enrolled in or discontinued from a clinical study involving an investigational agent or non-approved use of a drug or device, or concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study
Chemotherapy, immunotherapy and/or anticancer therapy (except for small molecule kinase inhibitors, which are 6 elimination half-lives)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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