Patient-Derived Xenografts to Reduce Cancer Health Disparities

  • End date
    Dec 18, 2023
  • participants needed
  • sponsor
    University of California, Davis
Updated on 4 October 2022
lung cancer
primary cancer
bladder cancer
bladder tumor
lung carcinoma


This trial establishes patient-derived cancer xenografts in addressing cancer health and treatment disparities that disproportionately affect racial/ethnic minorities. Understanding the genetic and response differences among racial/ethnic minorities may help researchers enhance the precision of therapeutic treatments.



I. Develop and characterize over 200 patient-derived xenografts (PDXs), with at least 50 PDXs each for gastric, liver, bladder, and lung cancers with 60% (approximately) of the PDXs from minority patients, focusing on Hispanic/Latino Americans [HLAs], African Americans [AAs], and Asian American/Native Hawaiians/Pacific Islanders [AANHPIs].

II. Utilize these PDXs in preclinical testing of single agents and drug combinations to guide precision cancer medicine decision-making with a focus upon the predominant racial/ethnic minority populations residing in California compared to non-Hispanic Whites [NHWs].

III. Conduct "Characterizing Treatment Responses with PDX Models for Gastric and Liver Tumors" as Research Project 1, focused on the most common histological forms of gastric cancer (GC) and liver cancers (LC) primarily from HLAs and AANHPI patients.

IV. Conduct "Characterizing Treatment Responses with PDX Models for Lung and Bladder Tumors" as Research Project 2, focused on lung squamous cell carcinoma (LSCC) and advanced urothelial or bladder cancer (aBC) primarily from AA and NHW patients.

V. Collaborate with the National Cancer Institute (NCI), other PDX Development and Trial Centers (PDTCs), non-PDXNet, PDXNet Data Commons and Coordinating Centers to fulfill the mission of the PDXNet.

VI. Select and conduct pilot projects through the Pilot Projects and Trans-Network Activities Core (PPTNAC) inclusive of UCaMP members, other PDTCs and beyond that will evaluate comparative therapeutic responses using PDX models and contribute to the elucidation of biological determinants of cancer health disparities in gastric, liver, bladder, and lung cancers.


Patients undergo collection of tumor tissue samples during standard of care tumor biopsy or surgical resection to establish PDXs. Patients may also undergo collection of blood, saliva, and urine samples to compare deoxyribonucleic acid (DNA) abnormalities to noncancer cells in order to determine if they were present before the cancer started or developed with it.

Condition Cancer, Neoplasms, Bladder Carcinoma, malignant tumor, carcinoma lung, Lung Neoplasm, Gastric Carcinoma, malignant tumors, Cancer/Tumors, Bladder Cancer, Ewing's Family Tumors, primary malignant neoplasm, carcinoma of the bladder, malignancy, Cancer (Pediatric), malignancies, Liver and Intrahepatic Bile Duct Carcinoma, Biliary Tract Cancer, bladder cancer, cancers, Urothelial Cancer, primary cancer, lung carcinoma, Lung Cancer
Treatment biospecimen collection
Clinical Study IdentifierNCT04410302
SponsorUniversity of California, Davis
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Patient receiving treatment for the above 4 cancers (bladder cancer, lung cancer, gastric/stomach cancer, and liver cancer)
Signed informed consent that will be put on file

Exclusion Criteria

No informed consent obtained
Specimen unacceptable/degraded/etc
Individuals who are not yet adults (infants, children, teenagers)
Pregnant women
Adults unable to consent
Clear my responses

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