A Phase 1/2 Trial of MRTX849 in Combination with TNO155 in Patients with Advanced Solid Tumors with KRAS G12C Mutation
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- STATUS
- Recruiting
Summary
Characterize the safety and tolerability, and evaluate Pharmacokinetics of MRTX849 in combination with TNO155 in patients with advanced solid tumor malignancies with KRAS G12C mutation.
- MRTX849 is an orally available small molecute inhibitor of KRASG12C.
- TNO155 is a selective, orally bioavailable allosteric inhibitor of wild type SHP2.
Description
- Phase 1/1b to establish the maximum tolerated dose of the combination of study drugs in patients with advanced solid tumor malignancies with a KRAS G12C mutation.
- Phase 2 to evaluate clinical activity of the combination of study drugs in selected solid tumor malignancies with KRAS G12C mutation.
Details
| Condition | Non-Small Cell Lung Cancer, All Solid Tumors, Solid Tumors, Advanced Malignancies, Colon Cancer, Metastatic Cancer |
|---|---|
| Clinical Study Identifier | TX245183 |
| Last Modified on | 19 February 2021 |
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