Biomarkers for Human Heart Failure

  • End date
    Dec 19, 2022
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 19 August 2021
myocardial infarction
decompensated heart failure
acute decompensated heart failure


The purpose of this study is to establish the various ranges of proteins that can be assayed in the plasma and urine from hospitalized patients with all classes of heart failure and/or STEMI (ST-segment elevation myocardial infarction)/NSTEMI (Non-ST-segment elevation myocardial infarction), as well as history reviews.


Schematic Design of the Study: Single blood draw, one random urine and 24-hr urine collection from hospitalized patients with chronic/acute heart failure and/or STEMI-NSTEMI. If there should be a subsequent hospitalization,another collection of a 45 ml blood sample, random urine and one 24-hour urine collection may be completed if indicated at initial hospitalization.


The purpose of this study is to attempt to establish the various ranges of proteins that can be assayed from the plasma and urine of patients with all classes of heart failure and MI (myocardial infarction). Follow-up hospitalizations may result in another 45 ml blood draw, random urine and 24-hr. urine collection to evaluate the outcome of the heart failure treatment used with the previous hospitalization, if indicated in consent. A history review will be necessary as well.

Condition Heart failure, Congestive Heart Failure, congestive heart disease
Treatment sample analysis
Clinical Study IdentifierNCT03905252
SponsorMayo Clinic
Last Modified on19 August 2021


Yes No Not Sure

Inclusion Criteria

Diagnosis of Acute decompensated heart failure

Exclusion Criteria

Hemoglobin less than 10, active cancer, or amyloidosis Patient with dialysis
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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