MOdified Urinary Conduit to Lower Strictures After radIcal Cystectomy

  • STATUS
    Recruiting
  • days left to enroll
    59
  • participants needed
    300
  • sponsor
    Jørgen Bjerggaard Jensen
Updated on 9 July 2021
radical cystectomy
cancer
bladder cancer
bladder tumor
urinary diversion
ileal conduit

Summary

Cystectomy is the chosen treatment of bladder cancer in 400 cases every year in DK. In replacement of the removed bladder, a urinary diversion is constructed using 15cm of terminal ilium (Ad Modum Bricker).

Ureteral strictures are diagnosed in 15% of the cystectomized patients, and these patients are at increased risk of infections, loss of renal function and repeated interventions. The left ureter is diagnosed with 70% of all strictures, presumably due to the construction of the urinary diversion.

A modified urinary diversion have been tested in two small studies. The modified diversion is prolonged with 5cm compared to the conventional urinary diversion. The prolongation permits the urinary diversion to reach both the left and the right side of the abdomen, resulting in greater resection of non-viably distal ureter and less mobilization of the left ureter, lowering the rates of strictures.

Details
Condition Bladder Cancer, carcinoma of the bladder, Urologic Cancer, Bladder Disorders, urinary tract neoplasm, Urothelial Cancer, bladder cancer, Bladder Carcinoma, bladder tumor, bladder disorder
Treatment Cystectomy and modified urinary conduit, Cystectomy and standard urinary conduit ad modum Bricker
Clinical Study IdentifierNCT04391790
SponsorJørgen Bjerggaard Jensen
Last Modified on9 July 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Bladder cancer with the indication for robot assisted radical cystectomy
Ileal conduit ad modum Bricker as planned urinary diversion
Ability to understand the participant information orally and in writing
Signed consent form

Exclusion Criteria

Previous abdominal or pelvic radiotherapy
Previous major abdominal surgery involving resection of bowel or construction of an enteric stoma
Urostomy planned on the left side of the abdomen
Single kidney
Complete ureteral duplication (either uni- or bilaterally), known at time of inclusion
Pregnancy
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