Comparison of the Live Birth Rate Between the PPOS and the GnRH Antagonist Protocol in Patients Undergoing IVF

  • STATUS
    Recruiting
  • End date
    Dec 27, 2023
  • participants needed
    784
  • sponsor
    ShangHai Ji Ai Genetics & IVF Institute
Updated on 27 April 2022
gonadotropin
hormone antagonist
antral
ovarian stimulation
dydrogesterone
in vitro fertilization
embryo transfer
antral follicle count
cetrorelix
gonadorelin

Summary

A randomized comparison of the live birth rate between the progestin-primed ovarian stimulation protocol and the gonadotrophin releasing hormone antagonist protocol in patients undergoing in vitro fertilization

Research question Does the live birth rate of the progestin-primed ovarian stimulation protocol comparable with the GnRH antagonist protocol for patients undergoing IVF?

Design This is a randomized controlled trial.

Research plan

Population: Infertile women who have medical indication for IVF will be recruited for study if they fulfil the selection criteria.

Intervention: Women will receive oral dydrogesterone 20mg daily from Day 3 till the day of ovulation trigger.

Comparator: Women will receive antagonist (Cetrorelix 0.25mg) once subcutaneously daily from day 6 of ovarian stimulation till the day of the ovulation trigger.

Outcomes: The primary outcome is the live birth rate the first FET.

Ovarian stimulation, egg retrieval, embryos frozen and frozen embryo transfer will be performed according to the standard operating procedures of the centres.

Details
Condition Infertility, ART
Treatment Duphaston, Cetrorelix
Clinical Study IdentifierNCT03680053
SponsorShangHai Ji Ai Genetics & IVF Institute
Last Modified on27 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age of women <43 years at the time of ovarian stimulation for IVF
Antral follicle count (AFC) on day 2-5 of the period≥5

Exclusion Criteria

Presence of a functional ovarian cyst with E2>100 pg/mL
Recipient of oocyte donation
Undergoing preimplantation genetic testing
Presence of hydrosalpinx which is not surgically treated or endometrial polyp on scanning during ovarian stimulation
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