A Randomized Trial Comparing the Live Birth Rate of Immediate Versus Delayed FET Following a Freeze-all Strategy (FET)

  • participants needed
  • sponsor
    ShangHai Ji Ai Genetics & IVF Institute
Updated on 20 September 2023
gnrh antagonist
ovarian stimulation
hormone replacement
intracytoplasmic sperm injection


This randomized trial we aim to compare the live birth rate of immediate versus delayed FET replacing a single blastocyst in the first FET of the first stimulated IVF cycle following. The hypothesis is that the live birth rate of the immediate FET is higher than the delayed FET replacing a single blastocyst in the first FET of the first stimulated IVF cycle following a freeze-all strategy. Women will undergo IVF/ICSI in the centre as clinically indicated. Standard ovarian stimulation with gonadotrophins in a Gonadotrophin releasing hormone (GnRH) antagonist protocol will be employed. Hormone replacement treatment (HRT) will be used in subsequent FET cycles. On Day 3 of the menstrual cycle, we will measure the anxiety levels using the Chinese State-Trait Anxiety Inventory and serum E2, cortisol levels will be checked on the same day.

Recruited women having the first FET cycle following a freeze all strategy will be randomly assigned on the day of blastocyst(s) freezing according to a computer-generated randomization list into one of the following two groups.

Condition IVF, Frozen Embryo Transfer
Treatment Immediate FET, Delayed FET
Clinical Study IdentifierNCT04371783
SponsorShangHai Ji Ai Genetics & IVF Institute
Last Modified on20 September 2023

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