Complete Local Response to Neoadjuvant Chemotherapy in Patients With Muscle Invasive Bladder Cancer Evaluated by 15O-H2O PET/MR

  • STATUS
    Recruiting
  • End date
    Mar 31, 2023
  • participants needed
    54
  • sponsor
    Jørgen Bjerggaard Jensen
Updated on 25 January 2021
radical cystectomy
cancer
metastasis
EGFR
bladder cancer
invasive bladder cancer
bladder tumor

Summary

Treatment of localized muscle invasive bladder cancer (MIBC) is radical cystectomy. Neoadjuvant chemotherapy (NAC) improves survival.

Approximately 50-60% of all MIBC patients undergoing NAC before cystectomy are histopathological without remnant tumor in the cystectomy specimen (T0). However, there is currently no optimal method to evaluate whether the patient is true T0 or has remnant tumor in need for consolidating radical treatment. The study aim is to investigate if 15O-H2O PET/MR can predict complete local response to neoadjuvant chemotherapy in patients with MIBC and thereby identify potential candidates for organ preservation.

Description

For patients with MIBC treated with NAC and radical cystectomy there is currently no good way of evaluating whether the patient is true T0 or has remnant tumor in need for consolidating radical treatment. Methods for better selection of patients that potentially can avoid cystectomy is therefore needed.

15O-labeled water (H2O) is the gold standard for PET quantification of regional tissue perfusion. 15O-H2O has been validated as a freely diffusible tracer for measuring perfusion in the myocardium and cerebral blood flow and 15O-H2O PET is the golden standard for noninvasive imaging to quantify tumor blood flow (TBF).

Method: Patients scheduled for NAC followed by radical cystectomy due to histologically documented MIBC stage cT2-4a in the urinary bladder will be included. A 15O-H2O PET/MR scan will be performed at time of inclusion (baseline) and again after NAC prior to cystectomy.

Hypothesis: We hypothesize that changes in tumor architecture and perfusion estimated with 15O-H2O PET/MR measurements and clinical evaluation during NAC can identify patients with complete local response to chemotherapy and therefore select patients to avoid radical cystectomy.

Perspectives: This study will be the first to use 15O-H2O as tracer in bladder cancer. If proven efficient, evaluation of patients undergoing NAC with 15O-H2O PET/MR could potentially safely select patients for a true bladder sparring approach and potentially give some patients the choice of chemotherapy monotherapy, or in combination with other systemic oncological treatments like immunotherapy. If successful, this should be followed by randomized studies to document the clinical benefit and potentially reduce cost and increase quality of life by safely selecting patients for bladder sparring treatment of bladder cancer.

Details
Condition urinary tract neoplasm, bladder cancer, bladder disorder, Urothelial Cancer, Bladder Disorders, Bladder Carcinoma, Urologic Cancer, carcinoma of the bladder, bladder tumor
Treatment 15O-H2O PET/MR
Clinical Study IdentifierNCT04321707
SponsorJørgen Bjerggaard Jensen
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Bladder Carcinoma or bladder disorder or urinary tract neoplasm or bladder cancer or Urothelial Cancer or Urologic Cancer or Bladder Disorders?
Do you have any of these conditions: carcinoma of the bladder or bladder disorder or Urologic Cancer or Bladder Carcinoma or urinary tract neoplasm or Bladder Disorders or bladder tumor o...?
Diagnosis of MIBC stage cT2-4a
Preoperative PET/CT of thorax, abdomen, and pelvis with no suspicion of organ metastases or lymph node metastasis outside the surgical field
years of age at the time of signing the Informed Consent Form. Renal function of eGFR > 60 ml/min/1,73 m2
Physically fit for NAC
Clinical decision with patient accept of NAC before cystectomy
Mentally healthy. Signed Informed Consent Form

Exclusion Criteria

Unfit for MRI
Claustrophobia
Problems with seating arrangements (e.g. pain or involuntary movement)
Maximal shoulder width larger than 55 cm
Circumference larger than 160 cm
Weight above 250 kg
Metallic implants or other metallic foreign bodies
Pacemaker, ICD, or pace electrodes
Clear my responses

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