In-depth Immunological Investigation of COVID-19. (COntAGIouS)

  • End date
    Mar 30, 2026
  • participants needed
  • sponsor
    Universitaire Ziekenhuizen Leuven
Updated on 4 October 2022
coronavirus infection


The COntAGIouS trial (COvid-19 Advanced Genetic and Immunologic Sampling; an in-depth characterization of the dynamic host immune response to coronavirus SARS-CoV-2) proposes a transdisciplinary approach to identify host factors resulting in hyper-susceptibility to SARS-CoV-2 infection, which is urgently needed for directed medical interventions.


The overall aim of this prospective study is to provide an in-depth characterization of clinical and immunological features of patients hospitalized in UZ Leuven because of SARS-CoV-2 infection. For this purpose, clinical data and blood, nasopharyngeal/rectal swab, and if safe, bronchoalveolar lavage (BAL) fluid and lung tissue samples will be collected from PCR- or CT-confirmed COVID-19 patients, with varying degrees of disease severity. Assessed characteristics will be compared between severe and non-severe COVID-19 patients, and between COVID-19 positive and negative ('control') patients.

Condition Coronavirus Infections
Treatment Patient sampling
Clinical Study IdentifierNCT04327570
SponsorUniversitaire Ziekenhuizen Leuven
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Patients >/= 18 years old AND
Hospitalised with PCR-confirmed and/or CT-confirmed SARS-CoV-2 disease

Exclusion Criteria

Age < 18 years old
No informed consent
Patients on cyclosporine/tacrolimus/sirolimus/everolimus therapy
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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