Optic Nerve Head Structural Response to IOP Elevation in Patients With Keratoconus

  • participants needed
  • sponsor
    NYU Langone Health
Updated on 27 November 2022
optical coherence tomography
brimonidine tartrate ophthalmic solution
intraocular pressure
slit lamp examination


The mechanism by which vision loss in glaucoma occurs is still unknown, but it is clear that increased Intraocular Pressure (IOP) is a major risk factor. It is also thought that the lamina cribrosa (LC) is a site of primary damage during the pathogenesis of the disease. The changes caused by intraocular pressure (IOP) modulation at the level of the optic nerve head and LC will be evaluated in the present study. Subjects with keratoconus exhibit abnormal collagen properties that can impair their LC behavior. By evaluating their lamina biomechanical response we can advance our understanding on the role of the lamina in glaucoma pathogenesis. A better understanding of the process will ultimately lead to improved detection and management of glaucoma.

It is hypothesized that subjects with keratoconus have an abnormal biomechanical response of the lamina cribrosa in response to IOP modulation.

Condition Keratoconus, Glaucoma
Treatment Optical Coherence Tomography (OCT), Pentacam, Ophthalmodynamometer, Goldmann applanation tonometer, ORA
Clinical Study IdentifierNCT03560609
SponsorNYU Langone Health
Last Modified on27 November 2022

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