Rheumatology Patient Registry and Biorepository

  • End date
    Jun 1, 2040
  • participants needed
  • sponsor
    Yale University
Updated on 14 October 2021
connective tissue disease
sjogren's syndrome
autoimmune disease
rheumatic diseases
prednisolone acetate ophthalmic suspension
polymyalgia rheumatica
reactive arthritis
rheumatoid arthritis
giant cell arteritis
adult onset still's disease
mixed connective tissue disease
ankylosing spondylitis
antiphospholipid syndrome
Accepts healthy volunteers


To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.


A rheumatology biorepository will be created to permit comparative analyses between the rheumatic diseases in order to increase the understanding of disease pathogenesis. Patients seen at Yale clinics diagnosed with rheumatic diseases are invited to participate in this study. These rheumatic diseases include, but are not limited to: adult onset Still's disease, ankylosing spondylitis, psoriatic arthritis, reactive arthritis, antiphospholipid syndrome, systemic lupus erythematosus, Behcet's disease, dermatomyositis, polymyositis, giant cell arteritis and other vasculitides, Lyme's disease, mixed connective tissue disease, polymyalgia rheumatica, rheumatoid arthritis, sarcoidosis, systemic sclerosis (scleroderma), Sjogren's syndrome, and undifferentiated connective tissue disease.

Condition Connective Tissue Diseases, Psoriasis, Sjogren's Syndrome, Arthritis and Arthritic Pain (Pediatric), Behçet Disease, Xerostomia, sarcoid, Psoriatic Arthritis, behcet's disease, Arthritis and Arthritic Pain, Congenital Skin Diseases, Musculoskeletal Disease, Polymyositis (Inflammatory Muscle Disease), progressive systemic sclerosis, Adult Onset Still's Disease, Polymyalgia Rheumatica (PMR), Polymyalgia Rheumatica, SYSTEMIC LUPUS ERYTHEMATOSUS, Reiter's Syndrome, Dry Mouth, Autoimmune Disease, Sarcoidosis, Reiter's syndrome, Lymphoproliferative Disorder, Rheumatism, Lyme Disease Vaccine, Autoimmune disease, Giant Cell Arteritis, Dermatomyositis (Connective Tissue Disease), Mixed Connective Tissue Disease, Anterior uveitis, Systemic Lupus Erythematosus, Ankylosing spondylitis, rheumatic, Ankylosing Spondylitis, Idiopathic Inflammatory Myopathies, reactive arthritis, Rheumatoid Arthritis (Pediatric), rheumatic diseases, Skin Conditions, Antiphospholipid Syndrome, Dermatomyositis, Myositis, Rheumatoid Arthritis, Psoriasis and Psoriatic Disorders, temporal arteritis, CONNECTIVE TISSUE DISEASE, Arthritis, Lyme Disease, Lymphoproliferative disorders, PSORIATIC ARTHRITIS, Polymyositis, Behcet's Syndrome, Anterior Uveitis, Dermatosis, Systemic sclerosis, Sicca Syndrome, Scleroderma, Musculoskeletal Diseases
Clinical Study IdentifierNCT04402086
SponsorYale University
Last Modified on14 October 2021


Yes No Not Sure

Inclusion Criteria

Age 18 years old
No chronic skin conditions
No diagnosis of a rheumatic autoimmune disease (e.g., lupus, rheumatoid arthritis)
Normal BMI

Exclusion Criteria

Unable to provide informed consent
Currently pregnant or nursing unless the study goal is to study pregnant or nursing woman
Allergies to lidocaine or epinephrine (skin biopsies)
A history of impaired wound healing (skin biopsies)
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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